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WNT3 - Wikipedia

From Wikipedia, the free encyclopedia

WNT3

Identifiers

Aliases

WNT3, INT4, TETAMS, Wnt family member 3

External IDs

OMIM: 165330; MGI: 98955; HomoloGene: 22527; GeneCards: WNT3; OMA:WNT3 - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)^[1]

Band	17q21.31-q21.32	Start	46,762,506 bp^[1]
Band	17q21.31-q21.32	End	46,833,154 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 E1\|11 67.5 cM	Start	103,664,976 bp^[2]
Band	11 E1\|11 67.5 cM	End	103,708,783 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

skin of abdomen

Hypothalamus

testicle

anterior cingulate cortex

skin of leg

right frontal lobe

dorsolateral prefrontal cortex

substantia nigra

right lobe of liver

gonad

Top expressed in

surface ectoderm

rhombic lip

labioscrotal swelling

pretectal area

intestinal villus

Ileal epithelium

embryo

embryo

embryonic organizer

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	receptor ligand activity protein domain specific binding frizzled binding protein binding signaling receptor binding
Cellular component	cytoplasm endocytic vesicle membrane Wnt signalosome endoplasmic reticulum lumen plasma membrane extracellular region Golgi lumen extracellular exosome extracellular space extracellular matrix
Biological process	cellular response to retinoic acid cell fate commitment Spemann organizer formation at the anterior end of the primitive streak head morphogenesis limb bud formation mammary gland epithelium development anatomical structure formation involved in morphogenesis mesoderm formation positive regulation of collateral sprouting in absence of injury negative regulation of axon extension involved in axon guidance dorsal/ventral axis specification axon guidance limb development multicellular organism development positive regulation of Wnt signaling pathway gamete generation canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation canonical Wnt signaling pathway involved in osteoblast differentiation cell morphogenesis canonical Wnt signaling pathway anterior/posterior axis specification embryonic forelimb morphogenesis anterior/posterior pattern specification embryonic hindlimb morphogenesis Wnt signaling pathway positive regulation of gene expression regulation of neurogenesis stem cell proliferation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in stem cell proliferation neuron differentiation regulation of signaling receptor activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7473


22415

Ensembl


ENSG00000108379 ENSG00000277641 ENSG00000277626


ENSMUSG00000000125

UniProt


P56703


P17553

RefSeq (mRNA)


NM_030753


NM_009521

RefSeq (protein)


NP_110380


NP_033547

Location (UCSC)

Chr 17: 46.76 – 46.83 Mb

Chr 11: 103.66 – 103.71 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.^[5]^[6]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.^[6]

References

^ ^a ^b ^c ENSG00000277641, ENSG00000277626 GRCh38: Ensembl release 89: ENSG00000108379, ENSG00000277641, ENSG00000277626 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000125 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Roelink H, Wang J, Black DM, Solomon E, Nusse R (Dec 1993). "Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene". Genomics. 17 (3): 790–2. doi:10.1006/geno.1993.1412. PMID 8244403.
^ ^a ^b "Entrez Gene: WNT3 wingless-type MMTV integration site family, member 3".

External links

GeneReviews/NIH/NCBI/UW entry on Tetra-Amelia Syndrome

Nusse R, Brown A, Papkoff J, et al. (1991). "A new nomenclature for int-1 and related genes: the Wnt gene family". Cell. 64 (2): 231. doi:10.1016/0092-8674(91)90633-A. PMID 1846319. S2CID 3189574.
Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell. 4 (12): 1267–75. doi:10.1091/mbc.4.12.1267. PMC 275763. PMID 8167409.
Liu P, Wakamiya M, Shea MJ, et al. (1999). "Requirement for Wnt3 in vertebrate axis formation". Nat. Genet. 22 (4): 361–5. doi:10.1038/11932. PMID 10431240. S2CID 22195563.
Gazit A, Yaniv A, Bafico A, et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–66. doi:10.1038/sj.onc.1202985. PMID 10557084. S2CID 2009505.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Katoh M (2002). "Molecular cloning and characterization of human WNT3". Int. J. Oncol. 19 (5): 977–82. doi:10.3892/ijo.19.5.977. PMID 11604997.
Katoh M (2002). "Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45". Int. J. Oncol. 20 (2): 373–7. doi:10.3892/ijo.20.2.373. PMID 11788904.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Niemann S, Zhao C, Pascu F, et al. (2004). "Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family". Am. J. Hum. Genet. 74 (3): 558–63. doi:10.1086/382196. PMC 1182269. PMID 14872406.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chiba H, Kobune M, Kato J, et al. (2005). "Wnt3 modulates the characteristics and cobblestone area-supporting activity of human stromal cells". Exp. Hematol. 32 (12): 1194–203. doi:10.1016/j.exphem.2004.08.010. PMID 15588944.
Yamamoto H, Komekado H, Kikuchi A (2006). "Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin". Dev. Cell. 11 (2): 213–23. doi:10.1016/j.devcel.2006.07.003. PMID 16890161.

v t e Signaling pathway: Wnt signaling pathway
Ligand	WNT1 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B WNT10A WNT10B WNT11 WNT16
Receptor	Frizzled LRP5 LRP6
Second messenger	Dishevelled GSK-3 APC Beta-catenin

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