Ensiklopedia Dunia

Lifestyle Khazanah Profil Baru Dram Lists Ensiklopedia

Technopedia Center

Faculty of Engineering and Computer Science
S1 Informatics S1 Information Systems S1 Information Technology S1 Computer Engineering S1 Electrical Engineering S1 Civil Engineering

faculty of Economics and Business
S1 Management S1 Accountancy

Faculty of Letters and Educational Sciences
S1 English literature S1 English language education S1 Mathematics education S1 Sports Education

DADLE - Wikipedia

From Wikipedia, the free encyclopedia

DADLE
Names

IUPAC name (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid
Other names • [D-Ala², D-Leu⁵]-Enkephalin • L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-Leucine • N-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)-D-Leucine • Tyr-D-Ala-Gly-Phe-D-Leu-OH
Identifiers
CAS Number	63631-40-3^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:234245
ChemSpider	5292936^N
ECHA InfoCard	100.059.337
PubChem CID	6917707
UNII	HB4QD9GL6F^Y
InChI InChI=1S/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1^N Key: ZHUJMSMQIPIPTF-IBURTVSXSA-N^N InChI=1/C29H39N5O7/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41)/t18-,22+,23+,24-/m1/s1 Key: ZHUJMSMQIPIPTF-IBURTVSXBS
SMILES N[C@H](C(N[C@H](C)C(NCC(N[C@@H](CC1=CC=CC=C1)C(N[C@H](CC(C)C)C(O)=O)=O)=O)=O)=O)CC2=CC=C(O)C=C2
Properties
Chemical formula	C₂₉H₃₉N₅O₇
Molar mass	569.659 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

DADLE ([D-Ala², D-Leu⁵]-Enkephalin) is a synthetic opioid peptide with analgesic properties. Although it is often considered a selective δ-opioid receptor agonist, it also binds to the μ₁ subtype of μ-opioid receptors.

Treatment with DADLE results in transient depression of mean arterial blood pressure and heart rate.^[1]^[2]

Its peptide sequence is Tyr-D-Ala-Gly-Phe-D-Leu.

References

^ "Medical Dictionary Online". Archived from the original on 2007-08-28. Retrieved 2007-11-10.
^ Online Medical Dictionary, enkephalin, leucine-2-alanine

Opioid receptor modulators

μ-opioid
(MOR)

Agonists
(abridged;
full list)

3-HO-PCP
7-Acetoxymitragynine
7-Hydroxymitragynine
ψ-Akuammigine
α-Chlornaltrexamine
α-Narcotine
Acetyldihydrocodeine
Acetylfentanyl
Acrylfentanyl
Adrenorphin (metorphamide)
AH-7921
Akuammicine
Akuammidine
Alfentanil
Anileridine
Apparicine
β-Endorphin
BAM-12P
BAM-18P
BAM-22P
Benzhydrocodone
Benzylmorphine
Bezitramide
Biphalin
BU08070
Buprenorphine
Butorphan
Butorphanol
Butyrfentanyl
BW373U86
Carfentanil
Casokefamide
Cebranopadol
Chloroxymorphamine
Codeine
DADLE
DAMGO (DAGO)
Dermorphin
Desmetramadol (desmethyltramadol)
Desomorphine
Deumitragynine
Dextromoramide
Dextropropoxyphene (propoxyphene)
Dezocine
Dimenoxadol
Dimethylaminopivalophenone
Eluxadoline
Diamorphine (heroin)
Dihydrocodeine
Dihydroetorphine
Dihydromorphine
Dinalbuphine sebacate
Diphenoxylate
Dipipanone
Dynorphin A
Embutramide
Endomorphin-1
Endomorphin-2
Eseroline
Ethylmorphine
Etorphine
Fentanyl
Fluorophen
Frakefamide
Furanylfentanyl
Hemorphin-4
Herkinorin
Hodgkinsine
Hydrocodone
Hydromorphinol
Hydromorphone
IBNtxA
Ketamine
Ketobemidone
Kratom
Laudanosine
Lefetamine
Leu-enkephalin
Levacetylmethadol
Levomethorphan
Levorphanol
Lexanopadol
Loperamide
Loxicodegol
LS-115509
Matrine
Meptazinol
Met-enkephalin (metenkefalin)
Methadone
Metkefamide
Metopon
Mitragynine
Mitragynine pseudoindoxyl
Morphiceptin
Morphine
Nalbuphine
Naloxone benzoylhydrazone (NalBzOH)
Nalmexone
Naltalimide
Neopine
NFEPP
Nicocodeine
Nicodicodine
Nicomorphine
Norketamine
Nufenoxole
Octreotide
Oliceridine
Oxycodegol
Oxymorphone-3-methoxynaltrexonazine (OM-3-MNZ)
Oripavine
Oxycodone
Oxymorphazone
Oxymorphonazine
Oxymorphone
Oxymorphone phenylhydrazone
OxyPNPH
Papaver somniferum (opium)
Pentazocine
Pericine
Pethidine (meperidine)
Phenazocine
Phencyclidine
Piminodine
Piritramide
PL-017
Prodine
Propiram
PZM21
Racemethorphan
Racemorphan
Remifentanil
Salsolinol
SC-17599
Sinomenine
Sufentanil
Tapentadol
Tetrahydropapaveroline
TH-030418
Thebaine
Thienorphine
Tianeptine
Tilidine
Tramadol
Trimebutine
TRIMU 5
TRV734
Tubotaiwine
U-47700
Valorphin
Viminol
Xorphanol

Antagonists

δ-opioid
(DOR)

Agonists

Antagonists

κ-opioid
(KOR)

Agonists

3CS-nalmefene
6'-GNTI
8-CAC
18-MC
14-Methoxymetopon
β-Chlornaltrexamine
β-Funaltrexamine
Adrenorphin (metorphamide)
Akuammicine
Alazocine (SKF-10047)
Allomatrine
Apadoline
Asimadoline
BAM-12P
BAM-18P
BAM-22P
Big dynorphin
Bremazocine
BRL-52537
Butorphan
Butorphanol
BW373U86
Cebranopadol
Ciprefadol
CR665
Cyclazocine
Cyclorphan
Cyprenorphine
Desmetramadol (desmethyltramadol)
Diamorphine (heroin)
Diacetylnalorphine
Difelikefalin
Dihydroetorphine
Dihydromorphine
Dinalbuphine sebacate
Diprenorphine
Dynorphin A
Dynorphin B (rimorphin)
Eluxadoline
Enadoline
Eptazocine
Erinacine E
Ethylketazocine
Etorphine
Fedotozine
Fentanyl
Gemazocine
GR-89696
GR-103545
Hemorphin-4
Herkinorin
HS665
Hydromorphone
HZ-2
Ibogaine
ICI-199,441
ICI-204,448
Ketamine
Ketazocine
Laudanosine
Leumorphin (dynorphin B-29)
Levallorphan
Levomethorphan
Levorphanol
Lexanopadol
Lofentanil
LPK-26
Lufuradom
Matrine
MB-1C-OH
Menthol
Metazocine
Metkefamide
Mianserin
Mirtazapine
Morphine
Moxazocine
MR-2034
N-MPPP
Nalbuphine
NalBzOH
Nalfurafine
Nalmefene
Nalodeine (N-allylnorcodeine)
Nalorphine
Naltriben
Niravoline
Norbuprenorphine
Norbuprenorphine-3-glucuronide
Noribogaine
Norketamine
Oripavine
Oxilorphan
Oxycodone
Pentazocine
Pethidine (meperidine)
Phenazocine
Proxorphan
Racemethorphan
Racemorphan
RB-64
Salvinorin A (salvia)
Salvinorin B ethoxymethyl ether
Salvinorin B methoxymethyl ether
Samidorphan
Spiradoline (U-62066)
TH-030418
Thienorphine
Tifluadom
Tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline)
U-50488
U-54494A
U-69593
Xorphanol

Antagonists

Nociceptin
(NOP)

Agonists

Antagonists

Others

Propeptides: β-Lipotropin (proendorphin)
Prodynorphin
Proenkephalin
Pronociceptin
Proopiomelanocortin (POMC)

Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)

This analgesic-related article is a stub. You can help Wikipedia by expanding it.

Categories:

Hidden categories:

UNIVERSITAS TEKNOKRAT INDONESIA | ASEAN's Best Private University
Jl. ZA. Pagar Alam No.9 -11, Labuhan Ratu, Kec. Kedaton, Kota Bandar Lampung, Lampung 35132
Phone: (0721) 702022
Email: pmb@teknokrat.ac.id

See also

References