Bromochlorosalicylanilide

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Bromochlorosalicylanilide
Clinical data

Other names	Bromosalicylchloranilide Multifungin Salifungin
ATC code	D01AE01 (WHO)
Identifiers
IUPAC name 5-Bromo-N-(4-chlorophenyl)-2-hydroxybenzamide
CAS Number	3679-64-9
PubChem CID	77254
ChemSpider	69679
UNII	6GK715PWMQ
ChEMBL	ChEMBL153192
CompTox Dashboard (EPA)	DTXSID80190256
ECHA InfoCard	100.020.870
Chemical and physical data
Formula	C₁₃H₉BrClNO₂
3D model (JSmol)	Interactive image
SMILES Brc2cc(C(=O)Nc1ccc(Cl)cc1)c(O)cc2

Bromochlorosalicylanilide is an antifungal.^[1] It may cause allergic contact dermatitis in some individuals.^[2]

References

^ Weuffen W, Wagner G, Singer D, Petermann M (1966). "2-Hydroxythiobenzamides and 2-hydroxythiobenzanilides. III. Fungicidal properties". Pharmazie. 21 (10): 613–19.
^ Buckley DB (May 1986). "Allergic contact dermatitis to bromsalicylchloranilide". Contact Dermatitis. 14 (5): 319. doi:10.1111/j.1600-0536.1986.tb05290.x. PMID 3743047. S2CID 71597136.

Wall/
membrane

Ergosterol
inhibitors

Imidazoles	Topical: bifonazole^‡ butoconazole chlormidazole^‡ climbazole clotrimazole^# croconazole^‡ eberconazole econazole fenticonazole^‡ flutrimazole isoconazole ketoconazole luliconazole miconazole^# neticonazole^‡ omoconazole^‡ oxiconazole sertaconazole sulconazole tioconazole Systemic: ketoconazole
Triazoles	Topical: efinaconazole fluconazole^# terconazole Systemic: fluconazole^# fosfluconazole fosravuconazole hexaconazole^‡ isavuconazole itraconazole^# oteseconazole posaconazole voriconazole^# Unknown: albaconazole^‡ ravuconazole^†
Thiazoles	Topical: abafungin^‡

Allylamines	Topical: naftifine terbinafine Systemic: terbinafine
Benzylamines	Topical: butenafine

Others

Intracellular

Pyrimidine analogues/ thymidylate synthase inhibitors	Systemic: flucytosine^#
Mitotic inhibitors	Systemic: griseofulvin^#
Aminoacyl tRNA synthetase inhibitors	Topical: tavaborole

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