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  3. D arm - Wikipedia
D arm - Wikipedia
From Wikipedia, the free encyclopedia
Transfer RNA

The D arm is a feature in the tertiary structure of transfer RNA (tRNA). It is composed of the two D stems and the D loop. The D loop contains the base dihydrouridine (D), for which the arm is named.[1] The D loop's main function is that of recognition. It is widely believed that it acts as a recognition site for aminoacyl-tRNA synthetase, an enzyme involved in the aminoacylation of the tRNA molecule.[1][2] The D stem is also believed to have a recognition role although this has yet to be verified.

It is a highly variable region and is notable for its unusual conformation due to the over-crowding on one of the guanosine residues. It appears to play a large role in the stabilization of the tRNA's tertiary structure. The role of the D nucleotide in tRNA structure has been demonstrated in a detailed study comparing the structure of the D arm of the Schizosaccharomyces pombe tRNAiMet with an unmodified uracil (U) to the structure with the modified D nucleotide.[3] Despite the importance of the D am in many tRNAs, the D arm is absent from some mitochondrial tRNAs from metazoa.[4]

References

  1. ^ a b Hardt, Wolf Dietrich; Schlegl, Judith; Erdmann, Volker A.; Hartmann, Roland K. (December 1993). "Role of the D arm and the anticodon arm in tRNA recognition by eubacterial and eukaryotic RNase P enzymes". Biochemistry. 32 (48): 13046–13053. doi:10.1021/bi00211a014. PMID 7694652.
  2. ^ Smith, Drew; Yarus, Michael (April 1989). "Transfer RNA structure and coding specificity". Journal of Molecular Biology. 206 (3): 489–501. doi:10.1016/0022-2836(89)90496-8. PMID 2469803.
  3. ^ Dyubankova, N.; Sochacka, E.; Kraszewska, K.; Nawrot, B.; Herdewijn, P.; Lescrinier, E. (2015). "Contribution of dihydrouridine in folding of the D-arm in tRNA". Organic & Biomolecular Chemistry. 13 (17): 4960–4966. doi:10.1039/C5OB00164A. ISSN 1477-0520. PMID 25815904.
  4. ^ Jühling, Frank; Pütz, Joern; Bernt, Matthias; Donath, Alexander; Middendorf, Martin; Florentz, Catherine; Stadler, Peter F. (April 2012). "Improved systematic tRNA gene annotation allows new insights into the evolution of mitochondrial tRNA structures and into the mechanisms of mitochondrial genome rearrangements". Nucleic Acids Research. 40 (7): 2833–2845. doi:10.1093/nar/gkr1131. ISSN 1362-4962. PMC 3326299. PMID 22139921.
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