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Dicoumarol - Wikipedia

From Wikipedia, the free encyclopedia

Dicoumarol
Clinical data

MedlinePlus	a605015
ATC code	B01AA01 (WHO)
Legal status
Legal status	US: Withdrawn from market
Pharmacokinetic data
Protein binding	plasmatic proteins
Metabolism	hepatic
Excretion	faeces, urine
Identifiers
IUPAC name 3,3'-Methylenebis(4-hydroxy-2H-chromen-2-one)
CAS Number	66-76-2^Y
PubChem CID	653
IUPHAR/BPS	6808
DrugBank	DB00266^N
ChemSpider	10183330^Y
UNII	7QID3E7BG7
KEGG	D03798^Y
ChEBI	CHEBI:4513^Y
ChEMBL	ChEMBL1466^Y
NIAID ChemDB	016070
CompTox Dashboard (EPA)	DTXSID8021729
ECHA InfoCard	100.000.575
Chemical and physical data
Formula	C₁₉H₁₂O₆
Molar mass	336.299 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C1Oc2ccccc2C(O)=C1CC3=C(O)c4ccccc4OC3=O
InChI InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2^Y Key:DOBMPNYZJYQDGZ-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Dicoumarol (INN) or dicumarol (USAN) is a naturally occurring anticoagulant drug that depletes stores of vitamin K (similar to warfarin, a drug that dicoumarol inspired). It is also used in biochemical experiments as an inhibitor of reductases.

Dicoumarol is a natural chemical substance of combined plant and fungal origin. It is a derivative of coumarin, a bitter-tasting but sweet-smelling substance made by plants that does not itself affect coagulation, but which is (classically) transformed in mouldy feeds or silages by a number of species of fungi, into active dicoumarol. Dicoumarol does affect coagulation, and was discovered in mouldy wet sweet-clover hay, as the cause of a naturally occurring bleeding disease in cattle.^[1] See warfarin for a more detailed discovery history.

Identified in 1940, dicoumarol became the prototype of the 4-hydroxycoumarin anticoagulant drug class. Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs.

It is given orally, and it acts within two days.

Uses

Dicoumarol was used, along with heparin, for the treatment of deep venous thrombosis. Unlike heparin, this class of drugs may be used for months or years.

Mechanism of action

Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin K, thus causing depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes. These compounds are not antagonists of Vitamin K directly—as they are in pharmaceutical uses—but rather promote depletion of vitamin K in bodily tissues allowing vitamin K's mechanism of action as a potent medication for dicoumarol toxicity. The mechanism of action of Vitamin K along with the toxicity of dicoumarol are measured with the prothrombin time (PT) blood test.

Poisoning

Overdose results in serious, sometimes fatal uncontrolled hemorrhage.^[2]

History

Dicoumarol was isolated by Karl Link's laboratory at University of Wisconsin, six years after a farmer had brought a dead cow and a milk can full of uncoagulated blood to an agricultural extension station of the university. The cow had died of internal bleeding after eating moldy sweet clover; an outbreak of such deaths had begun in the 1920s during The Great Depression as farmers could not afford to waste hay that had gone bad.^[3] Link's work led to the development of the rat poison warfarin and then to the anticoagulants still in clinical use today.^[3]

References

^ Kresge N, Simoni RD, Hill RL (February 2005). "Hemorrhagic sweet clover disease, dicumarol, and warfarin: the work of Karl Paul Link". Journal of Biological Chemistry. 280 (8): e6–e7. doi:10.1016/S0021-9258(19)62862-0.
^ Duff IF, Shull WH (March 1949). "Fatal hemorrhage in dicumarol poisoning; with report of necropsy". Journal of the American Medical Association. 139 (12): 762–766. doi:10.1001/jama.1949.02900290008003. PMID 18112552.
^ ^a ^b Wardrop D, Keeling D (June 2008). "The story of the discovery of heparin and warfarin". British Journal of Haematology. 141 (6): 757–763. doi:10.1111/j.1365-2141.2008.07119.x. PMID 18355382.

External links

Diseases Database (DDB): 30166

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Orbofiban Roxifiban Sibrafiban^§ Tirofiban
ADP receptor/P2Y₁₂ inhibitors	Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor
Prostaglandin analogue (PGI2)	Beraprost Iloprost Prostacyclin Treprostinil
COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal
Thromboxane inhibitors	Thromboxane synthase inhibitors Dipyridamole (+ aspirin) Picotamide Terbogrel Receptor antagonists Terbogrel Terutroban^§
Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal
Other	Cloricromen Ditazole Vorapaxar

Anticoagulants

Vitamin K antagonists
(inhibit II, VII, IX, X)

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	Low-molecular-weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide
Direct Xa inhibitors ("xabans")	Apixaban Betrixaban Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban