IFNA6

IFNA6
Identifiers
Aliases	IFNA6, IFN-alphaK, interferon alpha 6
External IDs	OMIM: 147566; MGI: 2667155; HomoloGene: 105727; GeneCards: IFNA6; OMA:IFNA6 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	21,351,378 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	88,562,696 bp
RNA expression pattern
	Top expressed in
	putamen; ; caudate nucleus; ; Brodmann area 9; ; amygdala; ; substantia nigra; ; hippocampus proper; ; occipital lobe; ; primary visual cortex; ; nucleus accumbens; ; hypothalamus;
	Top expressed in
	embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; type I interferon receptor binding; cytokine receptor binding;
Cellular component	extracellular region; extracellular space; cellular component;
Biological process	natural killer cell activation involved in immune response; B cell differentiation; defense response; B cell proliferation; blood coagulation; positive regulation of peptidyl-serine phosphorylation of STAT protein; humoral immune response; adaptive immune response; defense response to virus; type I interferon signaling pathway; response to exogenous dsRNA; T cell activation involved in immune response; cytokine-mediated signaling pathway; innate immune response; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	3443
	230396
	ENSG00000120235
	ENSMUSG00000063376
	P05013
	Q80SU4
	NM_021002
	NM_177347
	NP_066282
	NP_796321
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon alpha-6 is a protein that in humans is encoded by the IFNA6 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000120235 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
^ "Entrez Gene: IFNA6 interferon, alpha 6".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329. ( Pt 2) (2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120235 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1385305-5] Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.

[entrez-6] "Entrez Gene: IFNA6 interferon, alpha 6".

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Epstein Files Full PDF

References

Further reading