IFNA7

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IFNA7

From Wikipedia, the free encyclopedia

IFNA7

Identifiers

Aliases

IFNA7, IFN-alphaJ, IFNA-J, interferon, alpha 7, interferon alpha 7

External IDs

OMIM: 147567; MGI: 2667155; HomoloGene: 113762; GeneCards: IFNA7; OMA:IFNA7 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p21.3	Start	21,201,469 bp^[1]
Band	9p21.3	End	21,202,205 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4 C4\|4 42.02 cM	Start	88,561,878 bp^[2]
Band	4 C4\|4 42.02 cM	End	88,562,696 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

pancreatic ductal cell

tibialis anterior muscle

mucosa of ileum

skin of thigh

sural nerve

Top expressed in

embryo

embryo

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	cytokine activity type I interferon receptor binding cytokine receptor binding
Cellular component	extracellular region extracellular space
Biological process	defense response adaptive immune response response to exogenous dsRNA cell-cell signaling response to virus blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein natural killer cell activation involved in immune response B cell proliferation humoral immune response defense response to virus type I interferon signaling pathway B cell differentiation T cell activation involved in immune response cytokine-mediated signaling pathway innate immune response regulation of signaling receptor activity
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3444


230396

Ensembl


ENSG00000214042


ENSMUSG00000063376

UniProt


P01567


Q80SU4

RefSeq (mRNA)


NM_021057


NM_177347

RefSeq (protein)


NP_066401


NP_796321

Location (UCSC)

Chr 9: 21.2 – 21.2 Mb

Chr 4: 88.56 – 88.56 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interferon alpha-7 is a protein that in humans is encoded by the IFNA7 gene.^[5]^[6]

References

[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000214042 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
^ "Entrez Gene: IFNA7 interferon, alpha 7".

Conti L, Fantuzzi L, Del Cornò M, et al. (2005). "Immunomodulatory effects of the HIV-1 gp120 protein on antigen presenting cells: implications for AIDS pathogenesis". Immunobiology. 209 (1–2): 99–115. doi:10.1016/j.imbio.2004.02.008. PMID 15481145.
Capobianchi MR, Ankel H, Ameglio F, et al. (1992). "Recombinant glycoprotein 120 of human immunodeficiency virus is a potent interferon inducer". AIDS Res. Hum. Retroviruses. 8 (5): 575–9. doi:10.1089/aid.1992.8.575. PMID 1381203.
Tyring SK, Cauda R, Tumbarello M, et al. (1991). "Synthetic peptides corresponding to sequences in HIV envelope gp41 and gp120 enhance in vitro production of interleukin-1 and tumor necrosis factor but depress production of interferon-alpha, interferon-gamma and interleukin-2". Viral Immunol. 4 (1): 33–42. doi:10.1089/vim.1991.4.33. PMID 1905933.
Stine KC, Bolognesi D, Weinhold KJ (1989). "Cytokine augmentation of human immunodeficiency virus type 1 (HIV-1) gp120-specific cellular cytotoxicity". Journal of Biological Response Modifiers. 8 (5): 501–10. PMID 2552026.
Cohen S, Velan B, Grosfeld H, et al. (1985). "Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells". Dev. Biol. Stand. 60: 111–22. PMID 2995168.
Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
Ullrich A, Gray A, Goeddel DV, Dull TJ (1982). "Nucleotide sequence of a portion of human chromosome 9 containing a leukocyte interferon gene cluster". J. Mol. Biol. 156 (3): 467–86. doi:10.1016/0022-2836(82)90261-3. PMID 6181262.
Ameglio F, Capobianchi MR, Castilletti C, et al. (1994). "Recombinant gp120 induces IL-10 in resting peripheral blood mononuclear cells; correlation with the induction of other cytokines". Clin. Exp. Immunol. 95 (3): 455–8. doi:10.1111/j.1365-2249.1994.tb07018.x. PMC 1535081. PMID 7511078.
Ankel H, Capobianchi MR, Castilletti C, Dianzani F (1994). "Interferon induction by HIV glycoprotein 120: role of the V3 loop". Virology. 205 (1): 34–43. doi:10.1006/viro.1994.1617. PMID 7526537.
Nair MP, Chadha KC, Stadler I, et al. (1995). "Differential effects of human immunodeficiency virus type 1 envelope protein gp120 on interferon production by mononuclear cells from adults and neonates". Clin. Diagn. Lab. Immunol. 2 (4): 434–8. doi:10.1128/CDLI.2.4.434-438.1995. PMC 170174. PMID 7583919.
Borghi P, Fantuzzi L, Varano B, et al. (1995). "Induction of interleukin-10 by human immunodeficiency virus type 1 and its gp120 protein in human monocytes/macrophages". J. Virol. 69 (2): 1284–7. doi:10.1128/JVI.69.2.1284-1287.1995. PMC 188705. PMID 7815507.
Capobianchi MR, Ameglio F, Cordiali Fei P, et al. (1994). "Coordinate induction of interferon alpha and gamma by recombinant HIV-1 glycoprotein 120". AIDS Res. Hum. Retroviruses. 9 (10): 957–62. doi:10.1089/aid.1993.9.957. PMID 7904170.
Chen YH, Böck G, Vornhagen R, et al. (1994). "HIV-1 gp41 enhances major histocompatibility complex class I and ICAM-1 expression on H9 and U937 cells". Int. Arch. Allergy Immunol. 104 (3): 227–31. doi:10.1159/000236670. PMID 7913356.
Francis ML, Meltzer MS (1993). "Induction of IFN-alpha by HIV-1 in monocyte-enriched PBMC requires gp120-CD4 interaction but not virus replication". J. Immunol. 151 (4): 2208–16. doi:10.4049/jimmunol.151.4.2208. PMID 8345204.
Shirazi Y, Pitha PM (1993). "Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells". Virology. 193 (1): 303–12. doi:10.1006/viro.1993.1126. PMID 8438572.
Ankel H, Capobianchi MR, Frezza F, et al. (1996). "Interferon induction by HIV-1-infected cells: a possible role of sulfatides or related glycolipids". Virology. 221 (1): 113–9. doi:10.1006/viro.1996.0357. PMID 8661419.
Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
Schols D, De Clercq E (1996). "Human immunodeficiency virus type 1 gp120 induces anergy in human peripheral blood lymphocytes by inducing interleukin-10 production". J. Virol. 70 (8): 4953–60. doi:10.1128/JVI.70.8.4953-4960.1996. PMC 190447. PMID 8764000.
Hussain M, Gill DS, Liao MJ (1997). "Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population". J. Interferon Cytokine Res. 16 (10): 853–9. doi:10.1089/jir.1996.16.853. PMID 8910771.

Cytokine receptor modulators

Chemokine

See here instead.

CSF

Erythropoietin	Agonists: ARA-290 Asialo erythropoietin Carbamylated erythropoietin CNTO-530 Darbepoetin alfa Epoetin alfa Epoetin beta Epoetin delta Epoetin epsilon Epoetin gamma Epoetin kappa Epoetin omega Epoetin theta Epoetin zeta Erythropoietin (EPO) Erythropoietin-Fc Methoxy polyethylene glycol-epoetin beta (CERA/Mircera) Peginesatide Pegol sihematide (EPO-018B)
G-CSF (CSF3)	Agonists: Filgrastim Granulocyte colony-stimulating factor Lenograstim Leridistim Lipegfilgrastim Nartograstim Pegfilgrastim Pegnartograstim
GM-CSF (CSF2)	Agonists: Ecogramostim Granulocyte macrophage colony-stimulating factor Milodistim Molgramostim Regramostim Sargramostim Antibodies: Mavrilimumab Namilumab Otilimab
M-CSF (CSF1)	Agonists: Cilmostim Interleukin-34 Lanimostim Macrophage colony-stimulating factor Mirimostim Kinase inhibitors: Agerafenib
SCF (c-Kit)	See here instead.
Thrombopoietin	Agonists: Eltrombopag Pegacaristim Promegapoietin Romiplostim Thrombopoietin (THPO, MGDF)

Interferon

IFNAR (α/β, I)	Agonists: Albinterferon Interferon alpha (interferon alfa, IFN-α) Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21) Interferon alfa 2a Interferon alfa 2b Interferon alfa n1 Interferon alfacon-1 Interferon alpha-n3 Interferon beta (IFN-β) (IFNB1, IFNB3) Interferon beta 1a Interferon beta 1b Interferon kappa (IFN-ε/κ/τ/ζ, IFNK) Interferon omega (IFN-ω, IFNW1) Peginterferon alfa-2a Peginterferon alfa-2b Antibodies: Anifrolumab Faralimomab MEDI-545 Rontalizumab Sifalimumab Decoy receptors: Bifarcept
IFNGR (γ, II)	Agonists: Interferon gamma (IFN-γ) Interferon gamma 1b Antibodies: Emapalumab Fontolizumab
IFNLR (λ, III)	See IL-28R (IFNLR) here instead.

Interleukin

See here instead.

TGFβ

See here instead.

TNF

See here instead.

Others

JAK
(inhibitors)

JAK1	Abrocitinib Baricitinib Deuruxolitinib Filgotinib Momelotinib Oclacitinib Peficitinib Ruxolitinib Tofacitinib (tasocitinib) Upadacitinib
JAK2	Atiprimod AZD-1480 Baricitinib CHZ868 Cucurbitacin I (elatericin B, JSI-124) CYT387 Deuruxolitinib Lestaurtinib NSC-7908 NSC-33994 Pacritinib Peficitinib Ruxolitinib SD-1008 Tofacitinib (tasocitinib)
JAK3	Cercosporamide Decernotinib (VX-509) Peficitinib Ritlecitinib TCS-21311 Tofacitinib (tasocitinib) WHI-P 154 ZM-39923 ZM-449829
TYK2	Deucravacitinib

Others

Additional cytokines: Cardiotrophin 1 (CT-1)
FMS-like tyrosine kinase 3 ligand (FLT3L)
Leukemia/leukocyte inhibitory factor (LIF)
Oncostatin M (OSM)
Thymic stromal lymphopoietin (TSLP)

Additional cytokine receptor modulators: Emfilermin
Lestaurtinib
Midostaurin
Quizartinib
Sorafenib
Sunitinib

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References

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