The main female protagonist of the series. The youngest daughter of Noah and Lyka. She is the chosen one of the werewolves. Her ability as a werewolf can burn vampires using her hands when touched. She has stronger powers than her mother Lyka who bestows on her a special protection against vampires just before she dies.^[8]

The main male protagonist of the series. The son of Roman, the vampire and Ceres, a mortal. He is the first known child born out of such a union. He is the only human child who lives with the vampire community in his first seven years. His father wants to integrate him with the werewolf and mortal community, but his attempts at peace talks with Lyka fails because he is double-crossed by Magnus. He is later adopted by Simon Teodoro and grows up in the Teodoro household with Lucas, Simon's natural child. He is the chosen one of the vampires as he is the strongest vampire. He turns into a vampire after he dies in a battle against werewolves. He loves Lia and together with her defeats Magnus, Lucas and the Hybrid army.

Starts out as one of the minor antagonists of the series, she switches allegiance to Mateo and Lia and becomes one of their strongest allies. She is the adopted vampire daughter of Magnus Imperial. Her mother is bitten by Magnus while pregnant in a desperate attempt to sire the chosen vampire. Magnus raises her as the anointed “chosen one”, mistakenly believing Barang's prophecy that the savior would come from his lineage.^[9] Samantha grows up believing that she is the strongest vampire who would lead her clan in the battle against the werewolves and their Chosen One. She eventually learns that she is mistaken, and the "Chosen One" is Mateo. Samantha falls in love with Mateo and fulfills the third part of the prophecy, "the bite of pure love", by turning a dying Mateo into a vampire to save his life. She joins Roman's community of righteous vampires, betraying her own father, Magnus. She becomes one of Mateo's and Lia's strongest allies. Lucas injures her in battle through his venom, and she chooses to kill herself rather than become a hybrid.

The main antagonist of the series. He is the son of Simon Teodoro and adoptive brother of Mateo. His mother is a fourth generation Ungson clan, one of the powerful clans of the Wayas. He becomes a hybrid after Magnus bites him. He builds an army of Hybrids that threaten all vampires, humans and werewolves.

Lyka's colleague at the Waya Council and Lia's surrogate father and guardian after Lyka died. He protects Lia from the abusive Head Guardian / Lady Sentinel (term for female Lord Sentinel) Lucille Zaragoza. His daughter Miriam is Lia’s best friend.

The main female antagonist of the series. Former head guardian of the Waya who succeeds Lyka after Lyka resigns following her family's assassination by vampires. She will do everything to keep the leadership of the Waya council, going as far as destroying Lyka's legacy as the last guardian. She strips the orphaned Lia of her privileged status and relegates her to a life of servitude. She abuses and torments Lia. At the end, she realizes her errors and joins Lia and Mateo's forces. She kills Magnus but dies in the process.

The main male antagonist of the series. The founder and leader of Club Sangre, an organization of evil vampires that aims to eliminate all werewolves to save their race. He is Samantha Imperial's adoptive father. He is Roman's enemy who sabotages Roman's peace efforts with Lyka. He kills Lyka at the surprise raid of Lyka's home.

The female antagonist of the series. She is Magnus' lover, who turns him into a vampire because she is in love with him. She turns against Magnus at the end of the series and joins Mateo and Lia's alliances.

One of the minor antagonists of the series. The daughter of Lucille and a member of the Waya council. She has an antagonistic relationship with Lia since childhood and is desperately in love with Mateo. She chooses to align with Lia when she realizes her mother's self-serving actions. She saves Mateo from the public execution her mother orders, and joins the Luna forces in the last battle against Magnus’ Force.

A righteous vampire colleague of Roman. She served as Mateo’s foster mother during his childhood. She leads Roman's community and helps vampires transition from human blood drinkers to animal blood drinkers.

The owner of Simon Landholdings Inc. He is father to Lucas and adoptive father to Mateo, who rescues him from the streets. He trusts Mateo over Lucas.

Mateo’s father. He is founder of the community of righteous vampires, who only drink animal blood. He attempts to reach out to Lyka to begin peace talks between vampires and werewolves as he believes they can peacefully coexist. He believes vampires don’t need human blood to survive and his community proves this possible.

Jethro’s father, a seer who is powerless with foretelling future events but he passes the genes to his son Jethro. He is also in Lobo as a child, played by Nash Aguas who could communicate with animals.

Tikboy’s son who becomes a powerful seer. He is the blogger who posted the upcoming prophecy. Olive’s best friend who falls in love with her. His feelings are hurt when Olive chooses Gael over Jethro in the grand opening of La Liga Unida, an organization for the peaceful friendship of werewolves, vampires, and mortals.

Dara's niece and Jethro's love interest. Her first love is Jethro until she meets Gael who turns her into a vampire. She ends up having a mutual relationship with Gael.

A vampire ally of Magnus. He falls in love and has a mutual relationship with Olive. He switches his alliance to Lia and Mateo.

A member of the Waya's werewolf army and Lia's friend. He becomes Clarisse's boyfriend.

A member of the Waya's werewolf army, Lia's friend and Vergara's assistant.

The vampire best friend of Samantha who is in love with her.