Indium (111In) capromab pendetide

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Indium (¹¹¹In) capromab pendetide
Monoclonal antibody
Type	Whole antibody
Source	Mouse
Target	Glutamate carboxypeptidase II
Clinical data
Trade names	Prostascint
ATC code	V09IB04 (WHO)
Identifiers
CAS Number	151763-64-3^N (capromab) 148805-91-8 (pendetide)
ChemSpider	none
UNII	03MZ53X1YS
ChEMBL	ChEMBL1201579^N
^NY (what is this?) (verify)

Indium (¹¹¹In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.^[1] Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.^[2] Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single-photon emission computed tomography (SPECT).^[1]

Early trials with yttrium (⁹⁰Y) capromab pendetide were also conducted.^[3]

References

^ ^a ^b Manyak MJ (February 2008). "Indium-111 capromab pendetide in the management of recurrent prostate cancer". Expert Review of Anticancer Therapy. 8 (2): 175–81. doi:10.1586/14737140.8.2.175. PMID 18279057. S2CID 30587577.
^ WHO Drug Information
^ Kahn D, Austin JC, Maguire RT, Miller SJ, Gerstbrein J, Williams RD (April 1999). "A phase II study of [90Y] yttrium-capromab pendetide in the treatment of men with prostate cancer recurrence following radical prostatectomy". Cancer Biotherapy & Radiopharmaceuticals. 14 (2): 99–111. doi:10.1089/cbr.1999.14.99. PMID 10850293.

Diagnostic radiopharmaceuticals (V09)

Central nervous system

Skeletal system

^99mTc (Medronic acid)

Renal

Gastrointestinal/Hepatic

⁷⁵Se (SeHCAT)

Respiratory system

Cardiovascular system

Inflammation/infection

Tumor

Adrenal cortex

¹²³I
¹²⁵I / ¹³¹I (Iodocholesterol)

Radionuclides
(including tracers)

positron (PET list)

¹¹C ([¹¹C]ME@HAPTHI)
25B-NBOMe (Cimbi-36)
Acetate
Choline
Carfentanil
DASB
DTBZ
Flumazenil
Methionine
N-Methylspiperone
Pittsburgh compound B
Raclopride
Verapamil)
¹³N
- Ammonia
⁶⁴Cu
Desmethoxyfallypride
Fallypride
Florbetaben (18F)
Florbetapir (18F)
Flortaucipir (18F)
Flotufolastat F-18
Flubatine
Fluciclovine
Fludeoxyglucose (18F) (FDG)-glucose analogue
Flumazenil
¹⁸F (Altanserin)
Fluorocholine
Fluorodeoxysorbitol (FDS)
Fluorodopa
Fluoroestradiol F-18
Fluorothymidine F-18
Flurpiridaz (18F)
Fluspidine
Flutemetamol
FMISO
Gallium (⁶⁸Ga) gozetotide
⁶⁸Ga
Mefway
MPPF
N-Methylspiperone
Nifene
FET
¹⁵O (Water)
Piflufolastat F-18
⁸²Rb (Rubidium chloride)
Setoperone)

gamma ray/photon (SPECT/scintigraphy)

Isotopes used:

Monoclonal antibodies for tumors

Tumor

Human	Adecatumumab^§ Amivantamab Ascrinvacumab^§ Atezolizumab (+hyaluronidase) Balstilimab^† Botensilimab Cixutumumab^§ Conatumumab^§ Daratumumab Drozitumab^§ Duligotumab^§ Dusigitumab^§ Enfortumab vedotin Enoticumab^§ Figitumumab^§ Flanvotumab^§ Ganitumab^† Glembatumumab vedotin^† Intetumumab^§ Ipilimumab Iratumumab^§ Istiratumab Icrucumab^§ Lexatumumab^§ Lucatumumab^§ Mapatumumab^§ Narnatumab^§ Necitumumab Nesvacumab^§ Nivolumab^# Ofatumumab Olaratumab^† Panitumumab Patritumab^§ Pembrolizumab^# Pritumumab^§ Radretumab^§ Ramucirumab Rilotumumab^† Robatumumab^§ Seribantumab^§ Sugemalimab Tarextumab^§ Tisotumab vedotin Teprotumumab^† Tovetumab^§ Vantictumab^§ Votumumab^§ Zalutumumab^†
Mouse	Abagovomab Altumomab pentetate Anatumomab mafenatox Arcitumomab Bectumomab Blinatumomab Capromab pendetide Detumomab Edrecolomab Ibritumomab tiuxetan Igovomab Lilotomab Minretumomab Mitumomab Nacolomab tafenatox Moxetumomab pasudotox Naptumomab estafenatox Oregovomab Pemtumomab^† Racotumomab Satumomab pendetide Solitomab Taplitumomab paptox Nofetumomab merpentan Pintumomab Tenatumomab Tositumomab
Chimeric	Amatuximab^§ Bavituximab^§ Brentuximab vedotin Carotuximab^† Cetuximab Derlotuximab biotin^§ Dinutuximab Ecromeximab^§ Ensituximab^§ Futuximab^§ Girentuximab^† Indatuximab ravtansine^§ Isatuximab Loncastuximab tesirine Margetuximab Mirvetuximab soravtansine Rituximab^# Siltuximab Ublituximab Zolbetuximab
Humanized	Abituzumab^§ Alemtuzumab Axatilimab Belantamab mafodotin Bevacizumab Bivatuzumab mertansine^§ Brontictuzumab^§ Cantuzumab mertansine^§ Cantuzumab ravtansine^§ Cirmtuzumab Citatuzumab bogatox^§ Clivatuzumab tetraxetan Cofetuzumab pelidotin Dacetuzumab^§ Demcizumab^§ Dalotuzumab^§ Denintuzumab mafodotin^§ Elotuzumab Emactuzumab Emibetuzumab^§ Enoblituzumab^§ Epcoritamab Etaracizumab^§ Farletuzumab^§ Ficlatuzumab^§ Flotetuzumab^§ Gemtuzumab ozogamicin Glofitamab Imgatuzumab^§ Inotuzumab ozogamicin Labetuzumab^§ Lifastuzumab vedotin^§ Lintuzumab^§ Lorvotuzumab mertansine^§ Lumretuzumab^§ Matuzumab^§ Milatuzumab^§ Naxitamab Nimotuzumab^† Obinutuzumab Ocaratuzumab^§ Odronextamab Otlertuzumab^§ Onartuzumab^§ Oportuzumab monatox^† Parsatuzumab^§ Pertuzumab Pinatuzumab vedotin^§ Polatuzumab vedotin Rosmantuzumab Rovalpituzumab tesirine^† Sacituzumab govitecan Sibrotuzumab^§ Simtuzumab^§ Sofituzumab vedotin^§ Tacatuzumab tetraxetan^§ Tigatuzumab^§ Trastuzumab^# (+deruxtecan / +emtansine) Tucotuzumab celmoleukin^§ Vandortuzumab vedotin^§ Vanucizumab^§ Veltuzumab^§ Vorsetuzumab mafodotin^§ Zenocutuzumab
Rat/mouse hybrid	Catumaxomab Ertumaxomab^§
Chimeric + humanized	Depatuxizumab mafodotin^† Duvortuxizumab Ontuxizumab^§

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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