Kinesin-associated protein 3

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Kinesin-associated protein 3 - Wikipedia

From Wikipedia, the free encyclopedia

KIFAP3

Identifiers

Aliases

KIFAP3, FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1, kinesin associated protein 3

External IDs

OMIM: 601836; MGI: 107566; HomoloGene: 7799; GeneCards: KIFAP3; OMA:KIFAP3 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q24.2	Start	169,921,326 bp^[1]
Band	1q24.2	End	170,085,208 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 H2.1	Start	163,607,152 bp^[2]
Band	1\|1 H2.1	End	163,744,678 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Pons

orbitofrontal cortex

lateral nuclear group of thalamus

Brodmann area 46

frontal pole

postcentral gyrus

prefrontal cortex

ganglionic eminence

sperm

dorsolateral prefrontal cortex

Top expressed in

barrel cortex

facial motor nucleus

nucleus accumbens

prefrontal cortex

subiculum

pontine nuclei

Temporal Lobe

medial dorsal nucleus

anterior horn of spinal cord

superior colliculus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding kinesin binding intraciliary transport particle B binding protein phosphatase binding
Cellular component	intraciliary transport particle ciliary basal body cytosol centrosome Golgi apparatus kinesin complex microtubule cytoskeleton kinesin II complex photoreceptor connecting cilium condensed nuclear chromosome ciliary tip spindle microtubule endoplasmic reticulum periciliary membrane compartment axoneme cilium
Biological process	protein localization plus-end-directed vesicle transport along microtubule antigen processing and presentation of exogenous peptide antigen via MHC class II negative regulation of apoptotic process microtubule-based movement positive regulation of calcium-dependent cell-cell adhesion microtubule-based process signal transduction negative regulation of cell population proliferation retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum intraciliary transport involved in cilium assembly protein-containing complex assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


22920


16579

Ensembl


ENSG00000075945


ENSMUSG00000026585

UniProt


Q92845


P70188

RefSeq (mRNA)

NM_001204514 NM_001204516 NM_001204517 NM_014970 NM_001375830
NM_001375831


NM_010629 NM_001305643

RefSeq (protein)

NP_001191443 NP_001191445 NP_001191446 NP_055785 NP_001362759
NP_001362760


NP_001292572 NP_034759

Location (UCSC)

Chr 1: 169.92 – 170.09 Mb

Chr 1: 163.61 – 163.74 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Kinesin-associated protein 3 (KAP3) is a protein that in humans is encoded by the KIFAP3 gene.^[5]^[6] It is a non-motor, accessory subunit which co-oligomerizes with the motor subunits KIF3A and KIF3B or KIF3C, to form heterotrimeric kinesin-2 motor proteins. Kinesin-2 KAP subunits were initially characterized in echinoderms and mice.^[7]^[8]

Function

The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 Armadillo repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein.^[6] It has also been proposed to act as a clamp, stabilizing the C-terminal half ^[9] of the otherwise unstable stalk coiled-coil.

Interactions

KIFAP3 has been shown to interact with APC,^[10] SMC3^[11] and RAP1GDS1.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075945 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026585 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y (Dec 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J Biol Chem. 271 (43): 27013–7. doi:10.1074/jbc.271.43.27013. PMID 8900189.
^ ^a ^b "Entrez Gene: KIFAP3 kinesin-associated protein 3".
^ Wedaman KP, Meyer DW, Rashid DJ, Cole DG, Scholey JM (February 1996). "Sequence and submolecular localization of the 115-kD accessory subunit of the heterotrimeric kinesin-II (KRP85/95) complex". J. Cell Biol. 132 (3): 371–80. doi:10.1083/jcb.132.3.371. PMC 2120715. PMID 8636215.
^ Yamazaki H, Nakata T, Okada Y, Hirokawa N (August 1996). "Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8443–8. Bibcode:1996PNAS...93.8443Y. doi:10.1073/pnas.93.16.8443. PMC 38690. PMID 8710890.
^ Ahmed Z, Mazumdar S, Ray K (February 2020). "Kinesin associated protein, DmKAP, binding harnesses the C-terminal ends of the Drosophila kinesin-2 stalk heterodimer". Biochem Biophys Res Commun. 522 (2): 506–511. doi:10.1016/j.bbrc.2019.11.111. PMC 8407544. PMID 31784087.
^ Jimbo T, Kawasaki Y, Koyama R, Sato R, Takada S, Haraguchi K, Akiyama T (April 2002). "Identification of a link between the tumour suppressor APC and the kinesin superfamily". Nat. Cell Biol. 4 (4): 323–7. doi:10.1038/ncb779. PMID 11912492. S2CID 10745049.
^ Shimizu K, Shirataki H, Honda T, Minami S, Takai Y (March 1998). "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide". J. Biol. Chem. 273 (12): 6591–4. doi:10.1074/jbc.273.12.6591. PMID 9506951.

Function

Interactions

References

Further reading