Lipopolysaccharide binding protein

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Lipopolysaccharide binding protein - Wikipedia

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(Redirected from Lipopolysaccharide-binding protein)

LBP

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4M4D

Identifiers

Aliases

LBP, BPIFD2, lipopolysaccharide binding protein

External IDs

OMIM: 151990; MGI: 1098776; HomoloGene: 3055; GeneCards: LBP; OMA:LBP - orthologs

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q11.23	Start	38,346,482 bp^[1]
Band	20q11.23	End	38,377,013 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 H1\|2 78.72 cM	Start	158,148,413 bp^[2]
Band	2 H1\|2 78.72 cM	End	158,174,772 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right lobe of liver

testicle

tibialis anterior muscle

gastrocnemius muscle

muscle of thigh

appendix

deltoid muscle

subcutaneous adipose tissue

glutes

right lobe of thyroid gland

Top expressed in

gastrula

choroid plexus of fourth ventricle

decidua

Epithelium of choroid plexus

lumbar spinal ganglion

ankle

ankle joint

stroma of bone marrow

left lobe of liver

uterus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	lipoteichoic acid binding protein binding lipid binding signaling receptor binding lipopolysaccharide binding lipopeptide binding
Cellular component	membrane extracellular exosome extracellular region cell surface extracellular space
Biological process	detection of molecule of bacterial origin lipid transport toll-like receptor 4 signaling pathway immune system process leukocyte chemotaxis involved in inflammatory response cellular defense response cellular response to lipoteichoic acid defense response to bacterium lipopolysaccharide transport positive regulation of interleukin-8 production positive regulation of interleukin-6 production positive regulation of neutrophil chemotaxis positive regulation of toll-like receptor 4 signaling pathway positive regulation of chemokine production negative regulation of tumor necrosis factor production lipopolysaccharide-mediated signaling pathway opsonization defense response to Gram-negative bacterium positive regulation of tumor necrosis factor production response to lipopolysaccharide macrophage activation involved in immune response positive regulation of respiratory burst involved in inflammatory response acute-phase response innate immune response defense response to Gram-positive bacterium cellular response to lipopolysaccharide positive regulation of macrophage activation toll-like receptor signaling pathway macromolecule localization positive regulation of cytolysis transport cytokine-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3929


16803

Ensembl


ENSG00000129988


ENSMUSG00000016024

UniProt


P18428


Q61805

RefSeq (mRNA)


NM_004139


NM_008489

RefSeq (protein)


NP_004130


NP_032515

Location (UCSC)

Chr 20: 38.35 – 38.38 Mb

Chr 2: 158.15 – 158.17 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Lipopolysaccharide binding protein (LBP) is a protein that in humans is encoded by the LBP gene.^[5]^[6]

LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) to elicit immune responses by presenting the LPS to important cell surface pattern recognition receptors called CD14 and TLR4.^[7]

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). Finally, this gene is found on chromosome 20, immediately downstream of the BPI gene.^[6]

Clinical significance

LPS exposure induces LBP production.^[8] LBP is synthesized by the liver, adipose tissue, and intestinal cells.^[8] Dietary glucose and saturated fats acutely increase plasma LBP.^[8]

The proinflammatory activity of plasma LPS is increased by LBP, which is higher in obesity.^[9]

Plasma LBP is used as a better biomarker of plasma LPS than LPS itself due to the short half-life of LPS.^[8]

Interactions

Lipopolysaccharide-binding protein has been shown to interact with CD14, TLR2, TLR4 and the co-receptor MD-2.^[10]^[11]^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129988 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000016024 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gray PW, Corcorran AE, Eddy RL Jr, Byers MG, Shows TB (March 1993). "The genes for the lipopolysaccharide binding protein (LBP) and the bactericidal permeability increasing protein (BPI) are encoded in the same region of human chromosome 20". Genomics. 15 (1): 188–90. doi:10.1006/geno.1993.1030. PMID 8432532.
^ ^a ^b "Entrez Gene: LBP lipopolysaccharide binding protein".
^ Muta T, Takeshige K (2001). "Essential roles of CD14 and lipopolysaccharide-binding protein for activation of toll-like receptor (TLR)2 as well as TLR4 Reconstitution of TLR2- and TLR4-activation by distinguishable ligands in LPS preparations". Eur. J. Biochem. 268 (16): 4580–9. doi:10.1046/j.1432-1327.2001.02385.x. PMID 11502220.
^ ^a ^b ^c ^d Djuric Z (2017). "Obesity-associated cancer risk: the role of intestinal microbiota in the etiology of the host proinflammatory state". Translational Research. 179: 155–167. doi:10.1016/j.trsl.2016.07.017. PMC 5164980. PMID 27522986.
^ Tuomi K, Logomarsino JV (2016). "Bacterial Lipopolysaccharide, Lipopolysaccharide-Binding Protein, and Other Inflammatory Markers in Obesity and After Bariatric Surgery". Metabolic Syndrome and Related Disorders. 14 (6): 279–288. doi:10.1089/met.2015.0170. PMID 27228236.
^ Thomas CJ, Kapoor Mili, Sharma Shilpi, Bausinger Huguette, Zyilan Umit, Lipsker Dan, Hanau Daniel, Surolia Avadhesha (November 2002). "Evidence of a trimolecular complex involving LPS, LPS binding protein and soluble CD14 as an effector of LPS response". FEBS Lett. 531 (2): 184–8. doi:10.1016/S0014-5793(02)03499-3. ISSN 0014-5793. PMID 12417309. S2CID 25135963.
^ Yu B, Wright S D (1995). "LPS-dependent interaction of Mac-2-binding protein with immobilized CD14". J. Inflamm. 45 (2): 115–25. ISSN 1078-7852. PMID 7583357.
^ Erridge C, Pridmore A, Eley A, Stewart J, Poxton IR (2004). "Lipopolysaccharides of Bacteroides fragilis, Chlamydia trachomatis and Pseudomonas aeruginosa signal via toll-like receptor 2". Journal of Medical Microbiology. 53 (Pt 8): 735–40. doi:10.1099/jmm.0.45598-0. PMID 15272059.

External links

lipopolysaccharide-binding+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e Signaling pathway: TLR signaling pathway
TLRs	TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TLR10 TLR11 TLR12 TLR13
Other receptors	CD14 LBP MD2
Downstream signalling	IRAK1 IRAK2 IRAK3 IRAK4 IRF3 MAP3K7 MYD88 TAB1 TICAM1 TIRAP TOLLIP TRAF6

Categories:

Hidden categories:

Clinical significance

Interactions

References

Further reading

External links