Clinical data | |
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Trade names | Aivlosin |
AHFS/Drugs.com | Veterinary Use |
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Routes of administration | By mouth |
Drug class | Macrolide antibiotic |
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CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.058.284 |
Chemical and physical data | |
Formula | C53H87NO19 |
Molar mass | 1042.267 g·mol−1 |
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Tylvalosin, sold under the brand name Aivlosin, is a macrolide antibiotic used for the treatment of bacterial infections with Mycoplasma hyopneumoniae in swine, that causes enzootic pneumonia.[3][5] It is used as tylvalosin tartrate.[3]
Mechanism of Action
Macrolides are generally considered to be bacteriostatic agents that exert their antibiotic effect by reversibly binding to the 23S rRNA of the 50S ribosomal subunit, thereby inhibiting bacterial protein synthesis.[6]
Medical uses
Tylvalosin is indicated for the control of porcine proliferative enteropathy associated with Lawsonia intracellularis infection in groups of swine intended for slaughter and female swine intended for breeding in buildings experiencing an outbreak of PPE.[3] Not for use in male swine intended for breeding; and for the control of swine respiratory disease associated with Bordetella bronchiseptica, Glaesserella (Haemophilus) parasuis, Pasteurella multocida, Streptococcus suis, and Mycoplasma hyopneumoniae in groups of swine intended for slaughter and female swine intended for breeding in buildings experiencing an outbreak of swine respiratory disease.[3] Not for use in male swine intended for breeding.[3]
References
- ^ "Aivlosin- tylvalosin granule". DailyMed. 29 November 2021. Retrieved 13 December 2023.
- ^ "Aivlosin- tylvalosin tartrate granule, for solution". DailyMed. 29 November 2021. Retrieved 13 December 2023.
- ^ a b c d e f "Freedom of Information Summary Aivlosin NADA 141-336" (PDF). Retrieved 13 December 2023. This article incorporates text from this source, which is in the public domain.
- ^ "Aivlosin EPAR". European Medicines Agency (EMA). 8 January 2010. Retrieved 15 October 2024.
- ^ "Tylvalosin". TOKU-E. Retrieved 28 June 2024.
- ^ "Tylvalosin". TOKU-E. Retrieved 28 June 2024.
This article incorporates public domain material from US Food and Drug Administration. United States Department of Health and Human Services.