U.S. Route 101
US 101 highlighted in red
Route information
Maintained by Caltrans
Length	808.111 mi[1] (1,300.529 km) Portions of US 101 have been relinquished to or are otherwise maintained by local or other governments, and are not included in the length.
Existed	November 11, 1926 (1926-11-11)[2][3]–present
Tourist routes	Gaviota Coast[4] Redwood Highway through Del Norte Coast Redwoods State Park[5]
Restrictions	STAA trucks are prohibited through Richardson Grove State Park[6][7]
Major junctions
South end	I-5 / I-10 / SR 60 in Los Angeles
Major intersections	SR 110 in Los Angeles SR 134 / SR 170 in North Hollywood I-405 in Sherman Oaks I-280 / I-680 in San Jose I-280 in San Francisco I-80 in San Francisco I-580 in San Rafael SR 1 in Leggett SR 299 in Arcata US 199 near Crescent City
North end	US 101 at Oregon state line near Brookings, OR
Location
Country	United States
State	California
Counties	Los Angeles, Ventura, Santa Barbara, San Luis Obispo, Monterey, San Benito, Santa Clara, San Mateo, San Francisco, Marin, Sonoma, Mendocino, Humboldt, Del Norte
Highway system
United States Numbered Highway System List Special Divided State highways in California Interstate US State Scenic History Pre‑1964 Unconstructed Deleted Freeways
← SR 100 → SR 103

U.S. Route 101 (US 101) is a major north–south United States Numbered Highway, stretching from Los Angeles, California, to Tumwater, Washington. The California portion of US 101 is one of the last remaining and longest U.S. Routes still active in the state, and the longest highway of any kind in California.^[8] US 101 was also one of the original national routes established in 1926. Significant portions of US 101 between the Los Angeles area and the San Francisco Bay Area follow El Camino Real, the commemorative route connecting the former Alta California's 21 missions.

Although the highway has been superseded in overall importance for transportation through the state by Interstate 5 (I-5), US 101 continues to be the major coastal north–south route that links the Greater Los Angeles Area, the Central Coast, the San Francisco Bay Area, and the North Coast (Redwood Empire). Generally referred to as "101" by residents of Northern California, in Southern California it is often called "The 101" (pronounced "the one oh one").^[9] The highway has portions designated as the Santa Ana Freeway, the Hollywood Freeway, the Ventura Freeway, South Valley Freeway, and Bayshore Freeway, as well as El Camino Real in many non-freeway segments. The Redwood Highway, the 350-mile-long (560 km) northernmost segment of the highway, begins at the Golden Gate and passes through the world's tallest and only extensive preserves of virgin, old-growth coast redwood trees.

US 101 northbound as it enters downtown Los Angeles

View northward from the Cahuenga Pass, 1972

US 101 northbound approaching Gaviota Tunnel through the Santa Ynez Mountains

Downhill (southbound) view of Cuesta Grade north of San Luis Obispo

The Golden Gate Bridge, which carries US 101 and SR 1 between San Francisco and Marin County

US 101 follows the Russian River past Frog Woman Rock in southern Mendocino County

The US 101/US 199 interchange

The entirety of US 101 in California is designated as Route 101 in the state highway system, and is defined as such in section 401 of the California Streets and Highways Code:^[10]

Route 101 is from:

(a) Route 5 near Seventh Street in Los Angeles to Route 1, Funston approach, and, subject to Section 72.1, the approach to the Golden Gate Bridge in the Presidio of San Francisco via Santa Barbara, San Luis Obispo, and Salinas.

(b) A point in Marin County opposite San Francisco to the Oregon state line via Crescent City.

The definition purposely omits the segment crossing the Golden Gate Bridge, as it is maintained by the Golden Gate Bridge, Highway and Transportation District and is not part of the state highway system. As a result, there is no US 101 or SR 1 signage on the bridge.

US 101 is part of the California Freeway and Expressway System,^[11] and is part of the National Highway System,^[12] a network of highways that are considered essential to the country's economy, defense, and mobility by the Federal Highway Administration.^[13]

Portions of US 101 are eligible to be included in the State Scenic Highway System.^[14] It is officially designated as a scenic highway by the California Department of Transportation (Caltrans) from Goleta to Las Cruces in Santa Barbara County,^[4] and through Del Norte Coast Redwoods State Park in Del Norte County.^[5] This designation means that there are substantial sections of highway passing through a "memorable landscape" with no "visual intrusions", where the potential designation has gained popular favor with the community.^[15]

The south terminus of US 101 is in Los Angeles, about one mile (1.6 km) east of downtown Los Angeles at the East Los Angeles Interchange, also known as the "Commuters' Complex". This southernmost portion is named the Santa Ana Freeway, inheriting that title as the northerly extension of the roadway now known as I-5. US 101 heads north for 2 miles (3.2 km) before merging with the western end of the San Bernardino Freeway (I-10).

After merging with westbound traffic from the San Bernardino Freeway (I-10), US 101 then proceeds northwest via the Downtown Slot under the northern edge of Los Angeles' Civic Center to State Route 110 (SR 110) at the Four Level Interchange. From here, US 101 becomes the Hollywood Freeway. It then passes through the L.A. neighborhoods of Echo Park, Silver Lake, and Los Feliz and heads to Hollywood and up through the Cahuenga Pass before reaching the San Fernando Valley.

US 101 passes right next to the Universal Studios Hollywood and then intersects with SR 134 and SR 170 at the interchange known as the Hollywood Split. Here, the alignment of US 101 shifts to the alignment of SR 134 (i.e. heading northbound, the road's alignment turns left, or westbound) and thereafter is referred to as the Ventura Freeway until it reaches Ventura. Though confusing, the "Hollywood Freeway" name continues northward from this interchange on SR 170, and the "Ventura Freeway" name continues eastward to SR 134.

From the Hollywood Split, US 101 is an east–west highway (until it reaches Gaviota State Park in Santa Barbara County where it shifts back to a north–south alignment). It meets with I-405 in Sherman Oaks. The east–west geographical alignment of the Ventura Freeway and the north–south designation which appears on the freeway signs can be confusing to visitors; the same freeway entrance can often be signed as "101 North" and "101 West"; this is most common in the San Fernando Valley where the local E/W signing does not match the Caltrans' proper statewide N/S designation.^[16]

After the Conejo Grade, which is a 7% grade incline, the freeway enters the Oxnard Plain and runs concurrent with SR 1 for the first time. Upon reaching Ventura, there is an interchange with SR 126, which runs east to Santa Clarita.

North of Santa Barbara, US 101 switches intermittently between freeway and expressway status (i.e. there is occasional cross-traffic), but there are no traffic signals until San Francisco. From Ventura and through Santa Barbara, US 101 closely follows the Gaviota Coast (generally no more than one to two miles [1.6 to 3.2 km] from the shore) until Gaviota State Park, about 23 miles (37 km) west of Goleta. At Gaviota State Park, the highway shifts back from an east–west highway to a north–south alignment. About one mile (1.6 km) north of this point, the northbound lanes pass through the Gaviota Tunnel.

A few miles north of the Gaviota Tunnel, SR 1 splits from US 101 and heads northwest, running along the Pacific coastline parallel and to the west of US 101. US 101 passes through Buellton, Los Alamos, Orcutt, Santa Maria, and Nipomo. South of Santa Maria, US 101 widens from a four-lane highway to a six-lane freeway. SR 166 joins US 101 for about 3 miles (4.8 km) before splitting just north of the city limits, while US 101 continues as a four-lane freeway before reverting to expressway status north of Nipomo.

Farther north, SR 1 rejoins US 101 between Pismo Beach and San Luis Obispo. Then US 101 takes an inland route through the Salinas Valley, while Highway 1 heads northwest, running along the Pacific coastline in California, parallel and to the west of US 101.

A steep segment (7% grade) between San Luis Obispo and Atascadero is known as the Cuesta Grade. North of Atascadero, the highway joins SR 46 for about three miles (4.8 km) through Paso Robles.

From Paso Robles to Salinas, US 101 is an expressway known as the Salinas River Valley Highway, since the Salinas River Valley extends from Santa Margarita to the SR 156 junction in Prunedale. US 101 resumes freeway status between San Miguel and King City, bypassing the smaller towns of Camp Roberts, Bradley, and San Ardo, as well as the San Ardo Oil Field about five miles (8.0 km) south of San Ardo. Near this point, the wide agricultural bottomlands of the Salinas Valley begins. North of King City, US 101 once again switches intermittently between freeway and expressway status, passing through Greenfield, Soledad, Gonzales, and Chualar before reaching Salinas. Shortly after leaving Salinas, US 101 joins SR 156 in Prunedale for about eight miles (13 km). After crossing the San Benito County line, SR 156 splits from US 101 near San Juan Bautista while US 101 continues northward mostly as a four-lane highway until it reaches Gilroy.

US 101 crosses the Pajaro River into Santa Clara County as a four-lane highway, with an interchange at SR 25 a few miles later. Upon reaching Gilroy, it becomes the South Valley Freeway (as in South Santa Clara Valley), and at the same time, it expands to three lanes in each direction. It then enters Silicon Valley when reaching Morgan Hill, and shortly afterwards expands to four lanes in each direction, with an HOV lane in the middle, before reaching San Jose. From San Jose to San Francisco, US 101 is known as the Bayshore Freeway as it passes through Palo Alto and the other major communities along the San Francisco Peninsula.

US 101 is called the James Lick Freeway, named for James Lick, a philanthropist, from the San Francisco county/city line, through the interchange with I-280 at the Alemany Maze, until the junction with the San Francisco Skyway (I-80) and the Central Freeway near the city's Civic Center. US 101 continues in a northwestern direction on the Central Freeway, and then leaves the freeway, on Mission Street (northbound) and South Van Ness Avenue (southbound), to run north on Van Ness Avenue. At the intersection of Van Ness Avenue and Lombard Street, US 101 heads west on Lombard Street, and then on Richardson Avenue, entering The Presidio, where it becomes a divided highway again (the Presidio Parkway). It is then joined by Route 1 before approaching and crossing the Golden Gate Bridge.

From San Francisco north the highway is heavily traveled by commuters through to Windsor, just north of Santa Rosa. North of the Golden Gate Bridge, US 101 enters Marin County and is known as the Redwood Highway. After crossing the bridge, US 101 climbs the Waldo Grade and passes through the Robin Williams Tunnel, the only one of its kind in 300 miles (480 km) (the other being the Gaviota Tunnel in Santa Barbara County). Upon exiting the tunnel, it passes above the hillside town of Sausalito and descends to Richardson Bay, where SR 1 splits from the freeway and heads to the coast. US 101 then passes through Mill Valley, Corte Madera, Larkspur, San Rafael and Novato, before entering Sonoma County. The section between Novato in Marin County and Petaluma in Sonoma County changes from its original six or eight lanes through Marin to four lanes, creating a bottleneck, and is thus called the "Novato Narrows" by locals.^[17] The Narrows continue up to the county line between Marin and Sonoma Counties. The entire area between Novato and Petaluma is also the voter approved Novato–Petaluma Community Separator, which forbids most development.^[18]

Upon entering Sonoma County, the freeway widens again to six lanes from the county line to Windsor, passing through Petaluma, Cotati, Rohnert Park, and Santa Rosa. Upon reaching Windsor, the freeway returns to two lanes in each direction, crossing the Russian River in Healdsburg and then following the river up the Alexander Valley. SR 128 joins US 101 in the town of Geyserville before splitting just north of Cloverdale. US 101 then heads up a steep hill just before leaving Sonoma County and entering Mendocino County.

US 101 crosses into Mendocino County as a freeway for one mile (1.6 km), but then narrows to an expressway through the Russian River canyon and eventually a two-lane road south of Hopland, the first time since leaving San Francisco. Just before reaching Ukiah, US 101 becomes a four-lane freeway. In the community of Calpella, SR 20 merges with US 101 for the next 15.5 miles (24.9 km) to Willits. The freeway portion ends as the combined US 101 and SR 20 ascend the 1,956-foot (596 m) Ridgewood Summit, the highest elevation along the route's 808-mile-long (1,300 km) trek through California.^[19] As US 101 resumes freeway status just south of Willits, SR 20 splits from US 101 shortly before it suddenly reverts to a 2-lane undivided freeway and eventually a highway north of Willits.

US 101 then widens to a four-lane expressway until the intersection with the western portion of SR 162, where it reverts to a two-lane road. North of Laytonville, US 101 ascends Rattlesnake summit (1,796 feet or 547 metres) before a descent to follow the South Fork Eel River and Eel River all the way to Fortuna near the mouth of the river. About 12 miles (19 km) northwest of Laytonville, US 101 becomes an undivided freeway near the community of Cummings. SR 271 is the old portion of US 101 through this area. At Leggett, US 101 meets SR 1 for the last time, and from this point until Piercy, US 101 runs along a section of highway with frequent landslides. Caltrans bypassed the most difficult section in 2009 with unique construction of two bridges known collectively as the Confusion Hill Bridges. This project, funded by an emergency act from the State Legislature, moved the highway across the Eel River away from the troubled spots to prevent disruption in commerce and travel from infrequent, but costly, winter closures on the main transportation route to the far North Coast. North of Piercy, the freeway portion again ends and the road narrows down to two lanes, before another stretch of divided highway.

Arriving in Humboldt County, another narrow two-lane portion of US 101 bisects Richardson Grove State Park. Because of the narrow lanes and the redwood trees that tower over this segment of the highway, standard-sized trucks in compliance with the Surface Transportation Assistance Act (STAA) are prohibited through the park.^[6][7] Just after the park boundary, the highway switches to a short undivided freeway and then eventually a divided freeway just before reaching Garberville. North of Garberville, US 101 reverts to an undivided freeway, which continuing north by northwest, passes through the 53,000-acre (210 km²) Humboldt Redwoods State Park, California's third largest State Park and the site of the largest remaining Redwood old growth forest in the world. A preserved portion of the original, bypassed highway route, known as the Avenue of the Giants for the huge, centuries-old redwood trees, parallels the highway for over 30 miles (48 km) in southern Humboldt County. US 101 again switches to another stretch of divided freeway near the town Pepperwood before reverting to a short, 2-mile (3 km) expressway just north of Stafford. A short freeway then runs through Rio Dell before another short, 3-mile (5 km) expressway.

Shortly before reaching the western terminus of SR 36, US 101 becomes a freeway again between Fortuna and Eureka. North of Humboldt Hill, the road enters the City of Eureka (a potential new freeway cutting through or bypass of the city was successfully blocked repeatedly). As the route traverses Eureka, the southern portion is known as "Broadway" and then as it bears east along Humboldt Bay, the Highway is aligned on a one-way couplet (4th and 5th streets). Five miles (8.0 km) later the highway leaves Eureka's northern city limit and continues north. The expressway style section between Eureka and Arcata, which is also a safety corridor, is named the "Michael J. Burns Freeway," in honor of the State Senator who was a proponent of California's Highways. The highway becomes an unobstructed freeway south of the center of Arcata. Proceeding north it passes the junction for SR 299 (also the western terminus for that route), in the Valley West (northernmost) part of the college town.

The highway continues north as it skirts westerly around McKinleyville on a high bluff north of the Mad River. As the highway reaches Clam Beach (a county park), motorists get their first magnificent full view of the Pacific Ocean north of the Golden Gate. North of Trinidad, the highway narrows to one lane in each direction after crossing Big Lagoon to pass inland of Stone Lagoon and follow the coastal bar between Freshwater Lagoon and the Pacific Ocean south of Orick. It becomes a 14-mile (23 km) undivided freeway through Redwood National and State Parks running inland east of the Prairie Creek Redwoods State Park boundary. The freeway narrows to one lane in each direction at the Klamath River before losing its freeway designation in Klamath. The original placement of the highway near giant Coast Redwoods led to increased awareness of the destruction of the redwoods after decades of extensive logging, which ultimately led to the establishment of Redwood National Park in 1968. The original highway segment through Prairie Creek Redwoods State Park is now a scenic alternate similar to Avenue of the Giants, named Newton B. Drury Scenic Parkway in honor of the fourth director of the National Park Service and executive director of the Save-the-Redwoods League

North of the town of Klamath just inside Del Norte County, the highway closely follows the Pacific coast again. In Crescent City, US 101 once again separates into a one-way couplet (L and M Streets) for nine blocks. As it leaves Crescent City, US 101 becomes a divided freeway for the last time in California (built slightly to the west of the original two-lane alignment, now called Parkway Drive). As the 3-mile divided freeway portion ends, US 101 intersects the southern terminus of US 199, which heads northeast as the Redwood Highway, passing through the Collier Tunnel and terminating in Grants Pass, Oregon. US 101 (no longer called the "Redwood Highway" at this point) is reduced to two lanes and continues north along the California coast until it reaches the Oregon border.

High-occupancy toll (HOT) lanes along US 101 between SR 237 in Mountain View and Whipple Avenue in Redwood City opened on February 11, 2022.^[20][21] These express lanes were extended to I-380 in San Bruno on March 3, 2023,^[22] and are planned to be extended further south to I-880 in San Jose in Fall 2026.^[23]

As of August 2022^[update], the HOT lanes' hours of operation is weekdays between 5:00 am and 8:00 pm. Solo drivers are tolled using a congestion pricing system based on the real-time levels of traffic. Two-person carpools and clean air vehicles with a solo driver are charged 50 percent of the posted toll. Carpools with three or more people and motorcycles are not charged.^[24][25] All tolls are collected using an open road tolling system, and therefore there are no toll booths to receive cash. Each vehicle using the HOT lanes is required to carry either a FasTrak Flex or CAV (Clean Air Vehicle) transponder, with its switch set to indicate the number of the vehicle's occupants (1, 2, or 3 or more). Solo drivers may also use the FasTrak standard tag without the switch.^[24][25] Drivers without any FasTrak tag will be assessed a toll violation regardless of whether they qualified for free.^[26]

The segment of the express lanes in Santa Clara County is co-administered by the Santa Clara Valley Transportation Authority (VTA) while the segment in San Mateo County is co-administered by the separate San Mateo County Express Lanes Joint Powers Authority, and so drivers will see separate toll charges when using each segment.^[24][25]

Tolls are collected only for southbound traffic on the Golden Gate Bridge headed to San Francisco. Fully electronic tolling is also used on the bridge, and they can be paid by either a FasTrak transponder or license plate tolling. The high-occupancy vehicle (HOV) lane leading to the bridge requires a car with three or more people.^[27]

This section is missing information about the original construction and history behind this route. Please expand the section to include this information. Further details may exist on the talk page. (September 2020)

Distinctive route markers with symbolic mission bell and shepherd's crook are seen along the segments of US 101 that follow the historic El Camino Real between Los Angeles and Marin Counties

Early narrow concrete pavement survives on some former alignments like this stage route near Mission San Miguel Arcángel was designated US 101 until bypassed in 1938

Ferryboat Eureka at Hyde Street Pier with US 101 sign

Historic US 101 roadside attraction in Ukiah, now bypassed by the freeway

The US 101 Highway is part of the auto tour route of the Juan Bautista de Anza National Historic Trail, a National Park Service unit in the United States National Historic Trail and National Millennium Trail programs.^[28] In 2005, Caltrans began posting signs on roads that overlap with the historic 1776 Juan Bautista de Anza trail route, so that California drivers can now follow the trail.

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Instead of terminating in Los Angeles, US 101 once continued all the way south through San Diego to the Mexico–United States border in San Ysidro. However, this part was decommissioned on July 1, 1964, in favor of I-5. Though much of U.S. Route 101 has been superseded by I-5, several street segments of former Route 101 exist.

Much of the route in northern San Diego County is County Route S21; this includes Coast Highway in Oceanside, Carlsbad Boulevard in Carlsbad, Coast Highway 101 in Encinitas, Camino del Mar in Del Mar, and Torrey Pines Road in Torrey Pines. In San Diego, one alignment entered La Jolla Village on La Jolla Blvd, while a newer alignment went through Rose Canyon under what is now I-5. Roads followed by US-101 in San Diego included Mission Bay Drive, Pacific Hwy, Harbor Drive and Main Street. It ran along National City Blvd in National City, Broadway in Chula Vista and Beyer Blvd in San Ysidro.

By the early 1950s, traffic had become very heavy on US 101 through Oceanside and Carlsbad. The US 101 freeway bypass (Oceanside-Carlsbad freeway bypass) was built in 1953 and completed in 1955 by the California Department of Public Works (now Caltrans) and brought up by the San Diego Highway Development Association on a US 80/US 101 discussion on how to resolve the huge traffic loads on US 101 in Oceanside. Today it is part of I-5 and Palomar Airport Road. It follows I-5 from Coast Highway (former Hill Street exit) in Oceanside to Palomar Airport Road in Carlsbad. From there the US 101 bypass went onto Palomar Airport Road to merge with US 101 Bus. on Carlsbad Boulevard. As it approached the Coast Highway/SR 76 exit on southbound I-5 in Oceanside, US 101 Bus. split off. US 101 Bus. followed the original US 101 through downtown Oceanside and Carlsbad as former Hill Street/Carlsbad Boulevard (CR S-21) while the US 101 freeway followed modern I-5 and Palomar Airport Road. The south end of the freeway bypass is Carlsbad Boulevard and Palomar Airport Road and the north end is I-5 and the Coast Highway/SR 76 exit. The south end was modified after US 101 was decommissioned between the East Los Angeles Interchange in Los Angeles and the Mexican border in San Ysidro. This freeway construction by the California Department of Public Works put US 101 on an all new highway route alignment to relieve Oceanside and Carlsbad of their very heavy bumper-to-bumper burdensome traffic problem. Also before the bypass in the 1950s, US 101 followed North Coast Highway (formerly Hill Street) from San Luis Rey Mission Expressway (SR 76 and north end of the Oceanside–Carlsbad freeway bypass) to Harbor Drive. From there it followed Harbor Drive to Vandergrift Boulevard, San Rafael Drive, and the freeway onramp for I-5 north near the Camp Pendleton north entrance guardhouse gate. It merges with the I-5 northbound onramp to shoot onto the southbound lanes of I-5 to follow the freeway lanes all the way to Las Pulgas Road in Camp Pendleton.

An old orphaned alignment of US 101, that ran through the cities of Mission Viejo, Laguna Niguel, San Juan Capistrano, Dana Point, and San Clemente, was located in south Orange County. The old roadway, from a dead end just west of I-5 and east of the railroad tracks in Mission Viejo to Cristianitos Road in San Clemente, followed Camino Capistrano, Doheny Park Road, Coast Highway and El Camino Real. It had interchanges with I-5 and California State Route 1. It was replaced by the San Diego freeway (which US 101 became part of it in 1958) and finally replaced by I-5 in 1968.

In northern Orange County, US 101 followed Harbor Boulevard. U.S. Route 101 left Orange County, traversed southeast Los Angeles County, and entered the City of Los Angeles along Whittier Boulevard.

Significant portions of US 101 from its southern terminus to the San Francisco Bay Area is designated as the Royal Road or El Camino Real. The commemorative route connects the former Alta California's 21 missions.

A former route of the highway over the Gabilan Range on the San Juan Grade to San Juan Bautista was bypassed in a 1932 realignment. Instead, shortly after leaving Salinas, US 101 joins SR 156 in Prunedale for about eight miles (13 km) as it crosses the mountains further north, through the Prunedale Cutoff.

Before the Golden Gate Bridge was completed in 1937, there was regular vehicle ferry service across the Golden Gate strait, running from the Hyde Street Pier to Sausalito. Under the California Streets and Highways Code § 401, the Golden Gate Bridge is legally not part of US 101. The portion of US 101 starting from Los Angeles ends at "the approach to the Golden Gate Bridge" and then resumes at "a point in Marin County opposite San Francisco" to the Oregon state line. The bridge itself is maintained by the Golden Gate Bridge, Highway and Transportation District instead of Caltrans.

From the 1940s to 1991, various segments of US 101 between Los Angeles and San Francisco were upgraded to either a freeway or expressway. In the Los Angeles area, the first segment of the Hollywood Freeway through the Cahuenga Pass opened in 1940, while the segment from the San Fernando Valley to Downtown Los Angeles opened in 1954, replacing Cahuenga Boulevard.^[29] The Ventura Freeway then opened in 1960, replacing Ventura Boulevard.^[30] The segment of the original two-lane alignment between Emma Wood State Beach north to the Mobil Pier Undercrossing near Sea Cliff, which followed the historic Rincon Sea Level Road, was the re-signed as part of SR 1.

The last traffic signals along the route between the Los Angeles area and the San Francisco Bay Area were removed in 1991 when the section through downtown Santa Barbara was constructed to freeway standards after years of disagreement over the impact that the original elevated design would have on the community.^[31]

In the San Francisco Bay Area, US 101 was originally divided. US 101W followed the same general right-of-way of today's US 101 through the region, primarily along what was originally signed as Bayshore Boulevard. US 101E then generally followed the right-of-way taken by today's I-880 from San Jose to Oakland, then across the Carquinez Bridge to follow what is now SR 37, joining US 101W. The US 101E designation was removed by the 1940s and became SR 17 (later designated as I-880 and the westernmost section I-580), running from San Jose to Oakland and then across the Richmond–San Rafael Bridge. Meanwhile, Bayshore Boulevard was later redesignated as the US 101A bypass and then eventually upgraded to what is now the Bayshore Freeway. The first stretch that was completed between Redwood City and South San Francisco was the Bay Area's first freeway when it opened in 1947. After the entire Bayshore Freeway was completed in the early 1960s, the old alignment along the peninsula was renumbered and renamed as SR 82/El Camino Real.

Various other freeway or expressway bypasses along the California Central Coast were also built. In 1991, the last traffic signal along US 101 between Los Angeles and San Francisco was taken down in Santa Barbara.^[32] The primary control city that is listed on freeway signs along northbound US 101 through the Central Coast region remains San Francisco.

As the result of freeway revolts in San Francisco in the 1950s, a direct freeway connection through the city to the Golden Gate Bridge has never been built. The Central Freeway was completed to extend from the Bayshore Freeway to Turk Street in 1959,^[33][34] before the San Francisco Board of Supervisors voted to remove the remainder of the Central Freeway and most other proposed freeways from the city's highway plan.^[35] For decades, southbound traffic on US 101 flowed on the one-way Turk Street from Van Ness Avenue to the Central Freeway, while northbound traffic used the parallel Golden Gate Avenue. After the 1989 Loma Prieta earthquake damaged the structure, the segment of the Central Freeway north of Market Street was replaced with the surface-level Octavia Boulevard; traffic on US 101 was then eventually re-routed to exit south of that at Mission Street/South Van Ness Avenue. With no direct freeway along US 101 through the City of San Francisco, the old US 101E/I-880/I-580 route remains as a faster bypass through the Bay Area.

In the wake of the dot-com bubble expansion, the segment of US 101 between Morgan Hill and San Jose, also known as the Sig Sanchez Freeway, expanded to eight lanes between Cochrane Road and SR 85 exits between 2001 and 2003 and a new interchange at Bailey Avenue, which had been planned since the 1970s, opened in 2004.^[36] Originally, the ten-mile segment (16 km) was only four lanes (it was planned to have six lanes when opened in 1984).^[37] The rebuilt segment was to alleviate the consistent congestion that had expanded as far south as Masten Avenue coming from Gilroy, and as far north as Bernal Road coming from San Jose.^[38][39] Traffic now typically only runs slow between the Bailey Avenue and East Dunne Avenue exits.^{[citation needed]}

The interchange at the beginning of I-280 and I-680 in San Jose was constructed years before its completion. The three flyovers, with no on ramps or off ramps connecting them stood at 110-foot-tall (34 m) over US 101 for years in the 1970s (the SR 87/I-280 interchange also had this at the same time). It became the butt of many local jokes. The highlight prank occurred in January 1976, when a 1960 Chevrolet Impala was placed on the highest bridge overnight, where it obviously would be impossible to drive. The following day, San Jose City Councilman Joe Colla was photographed standing next to the car, a photo which was circulated across many newspapers.^[40] It has been suggested this stunt helped lead to funding to complete the freeway. In 2010, the interchange was named the Joe Colla Interchange.^[41]

An abandoned segment of the Redwood Highway, US 101, located in the Redwood National and State Parks near Klamath was added to the National Register of Historic Places in 1979.^[42]

Freeway segments along the Redwood Highway portion of US 101 are not as prevalent as along the Los Angeles-San Francisco route. A notable segment of the old US 101 alignment is SR 254, also known as the Avenue of the Giants, in Humboldt Redwoods State Park. The freeway bypassing this scenic route, surrounded by towering Coast Redwoods, was completed in 1960.^[43] Several bridges along the segment of highway running along the Eel River were destroyed during the Christmas flood of 1964.

A freeway bypass of Cloverdale was constructed in the early 1990s, requiring the relocation of segments of the Northwestern Pacific Railroad.^[44] The new 4-mile-long (6.4 km) roadway along with new frontages and relocated railroad were completed at a cost of $40 million ($82.2 million in 2023 adjusted for inflation).^[45] The highway opened over two weeks in March 1994.^[46] The old routing through town is on Cloverdale Boulevard.^[45]

Construction on a freeway segment bypassing Willits began in 2013.^[47] The bypass around Willits remained controversial because the intended route goes through protected wetlands. Construction was halted by US Army Corps of Engineers in June 2014 and work restarted the following month after Caltrans committed to extensive mitigation of the project.^[48][49] The 5.9 mi (9.5 km) bypass around Willits opened to traffic in November 2016.^[50] The bypass included a 1.1 mi (1.8 km) viaduct going over a flood plain.^[51] The freeway segment cost $459 million to complete ($583 million in 2023 adjusted for inflation), 50% more than what Caltrans first reported when it opened.^[52]

The city of Eureka has long resisted a freeway through it.^[53]

The Wallis Annenberg Wildlife Crossing is a vegetated overpass spanning the Ventura Freeway and Agoura Road at Liberty Canyon in Agoura Hills. Once built, it will be one of the largest urban wildlife crossings in the United States, connecting the Simi Hills and the Santa Monica Mountains over a busy freeway with ten traffic lanes (including exit lanes).^[54][55]

The Richardson Grove section of US 101 has been proposed for a bypass for many years, but Caltrans conducted a study in 2000 which stated that a bypass was not cost effective and recommended realignment of US 101 within the redwood grove instead to accommodate modern-sized trucks in compliance with the Surface Transportation Assistance Act (STAA).^[6][7]

Urban portions of the route in Southern California are named the Santa Ana Freeway,^[56] Hollywood Freeway, and Ventura Freeway at various points between East Los Angeles and Carpinteria, California.^[57] In 2008, the portion of US 101 that runs from the Conejo Grade to the Old Town district of Camarillo was dedicated as the Adolfo Camarillo Memorial Highway to honor the city's namesake and extends through the boundaries of the original Camarillo family ranch.^[58] In 2003, the portion of US 101 in Ventura County was named Screaming Eagles Highway in honor of the US Army 101st Airborne Division.^[59] Urban portions of the route in the Bay Area are called the James Lick Freeway, Bayshore Freeway, and Central Freeway. A portion of the route between Cochrane Road in Morgan Hill and SR 85 in San Jose is named the Sig Sanchez Freeway. The section of highway between SR 85 in Mountain View and Embarcadero Road in Palo Alto is officially known as the Frederick E. Terman Highway. Street routings in San Francisco are more commonly referred to by their street names rather than the route number. Portions of the route between Southern California and the Bay Area are named El Camino Real or El Camino Real Freeway, but such names are rarely used colloquially; the route number is used instead. In Northern California the section of US 101 between Sonoma and Marin counties is often referred to as the Novato Narrows because of the reduction from six lanes to four.

Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage. R reflects a realignment in the route since then, M indicates a second realignment, L refers to an overlap due to a correction or change, and T indicates postmiles classified as temporary (for a full list of prefixes, see California postmile § Official postmile definitions).^[1] Segments that remain unconstructed or have been relinquished to local control may be omitted. The numbers reset at county lines; the start and end postmiles in each county are given in the county column.

County	Location	Postmile [1][60][61]	Exit [62]	Destinations	Notes
Los Angeles LA S0.00-38.19	Los Angeles	​	—	I-5 south (Santa Ana Freeway south) – Santa Ana	No access to I-5 north; southern terminus of US 101; southern end of East Los Angeles Interchange
		​	—	Euclid Avenue	Southbound exit and northbound entrance
		​	—	SR 60 east (Pomona Freeway) / Soto Street – Pomona	Southbound exit and northbound entrance; northern end of East Los Angeles Interchange proper; SR 60 west exit 1C
		S0.00	1A	Seventh Street	Southbound exit and northbound entrance
		​		Whittier Boulevard	Northbound entrance only
		S0.62	1A	Fourth Street	No northbound entrance; signed as exit 1B southbound
		S0.91	1B	First Street	No southbound entrance; signed as exit 1C southbound
		​	1C	Cesar Chavez Avenue	Northbound exit only; was formerly Brooklyn Avenue
		S1.33 0.00	1D	I-10 east (San Bernardino Freeway) – San Bernardino	No southbound entrance, was demolished in 1996 due to seismic issues;[63][self-published source?]; San Bernardino Split portion of the East Los Angeles Interchange; access to I-10 east via the San Bernardino Freeway spur; no access to I-10 west; left exit southbound; I-10 west exit 19B; former western terminus of US 60 / US 70; former US 99 south; former I-110 east (1958–1965)
		0.10	1E	Mission Road	No northbound exit
		0.62	2A	Vignes Street	Northbound exit and entrance
		0.62– 0.82	2A-B	Alameda Street – Union Station	Signed as exit 2A southbound, 2B northbound
		0.82	2B	Los Angeles Street	No northbound exit
		1.10	2C	Spring Street	Northbound exit only
		1.10	2C	Broadway	Southbound exit and northbound entrance
		1.40	3A	Temple Street	Southbound exit and entrance
		1.57	3	SR 110 to I-110 south (Harbor Freeway, Arroyo Seco Parkway) / Grand Avenue – Pasadena, San Pedro	Northern end of Santa Ana Freeway; southern end of Hollywood Freeway[64] Four Level Interchange; Grand Avenue not signed southbound; signed as exit 3B southbound; SR 110 exit 24A
		2.48	4A	Glendale Boulevard, Echo Park Avenue, Union Avenue	Union Avenue not signed northbound; Echo Park Avenue not signed southbound
		2.86	4B	SR 2 east (Alvarado Street)	Southern end of SR 2 overlap
		3.34	5A	Rampart Boulevard, Benton Way
		3.76	5B	Silver Lake Boulevard
		4.40	6A	Vermont Avenue
		4.85	6B	Melrose Avenue, Normandie Avenue
		5.55	7	SR 2 west (Santa Monica Boulevard) / Western Avenue	Northern end of SR 2 overlap
		6.25	8A	Sunset Boulevard	No northbound entrance
		6.52	8B	Hollywood Boulevard
		6.91	8C	Gower Street
		7.06	9A	Vine Street	Southbound exit only
		7.46	9B	Cahuenga Boulevard – Hollywood Bowl	Signed as exit 9A northbound
		7.84	9C	Highland Avenue – Hollywood Bowl	Former SR 170 south; signed as exit 9B northbound
		8.84	Cahuenga Pass, elevation 745 feet (227 m)[65]
		9.22	11A	Barham Boulevard – Burbank	No southbound exit, which was permanently closed on October 17, 2015, due to weaving concerns with the construction of the new Universal Studios Boulevard southbound onramp.[66]
		9.60	11B	Universal Studios Boulevard	No southbound exit; serves Universal Studios Hollywood
		10.34	12A	Lankershim Boulevard – Universal City	Serves Universal Studios Hollywood
		10.56	12B	Ventura Boulevard	No southbound exit
		11.11	12C	Vineland Avenue to SR 134 east – Pasadena	Signed as exit 12B southbound
		​		Moorpark Street	Northbound entrance only
		11.80	13	SR 170 north (Hollywood Freeway north) – Sacramento	Northbound left exit and southbound left entrance; US 101 north transitions onto Ventura Freeway west;[64] southern end of Hollywood Split; SR 170 south exit 5A
		11.65	13B	SR 134 east (Ventura Freeway east) – Pasadena	Southbound exit and northbound entrance; US 101 south transitions onto Hollywood Freeway south;[64] northern end of Hollywood Split; SR 134 west exit 1A
		11.83	13A	Tujunga Avenue to SR 170 north	Southbound exit and northbound entrance
		12.85	14	Laurel Canyon Boulevard – Studio City
		13.88	15	Coldwater Canyon Avenue
		14.89	16	Woodman Avenue
		15.91	17	Van Nuys Boulevard
		16.94	18	Sepulveda Boulevard	Northbound exit and southbound entrance
		17.17	19A	I-405 (San Diego Freeway) – Santa Monica, Sacramento	I-405 exit 63B
		17.50	19B	Haskell Avenue	No southbound entrance
		18.61	20	Hayvenhurst Avenue	Northbound exit and southbound entrance
		19.22	21	Balboa Boulevard – Encino
		20.23	22	White Oak Avenue
		21.25	23	Reseda Boulevard
		22.25	24	Tampa Avenue
		23.26	25	Winnetka Avenue – Woodland Hills
		24.31	26A	De Soto Avenue, Serrania Avenue	Signed as exit 26 southbound
		24.85	26B	Canoga Avenue	Northbound exit and southbound entrance
		25.34	27	SR 27 (Topanga Canyon Boulevard) / Ventura Boulevard	Signed as exits 27A (north) and 27B (south) northbound
		25.76	27C	Shoup Avenue	Northbound exit and southbound entrance
		26.45	28	Fallbrook Avenue	Southbound exit only
		26.86	28	Woodlake Avenue	Northbound exit and entrance
		27.36	29	Mulholland Drive, Valley Circle Boulevard
	Calabasas	28.29	30	Parkway Calabasas
		31.06	32	Las Virgenes Road (CR N1) – Malibu Canyon
		31.92	33	Lost Hills Road
	Agoura Hills	32.79	34	Liberty Canyon Road
​		Wallis Annenberg Wildlife Crossing (planned to open in 2024[67])
33.69		35	Chesebro Road
35.04		36	Kanan Road (CR N9)
36.18		38	Reyes Adobe Road
Westlake Village	37.54	39	Lindero Canyon Road
Ventura VEN 0.00-R43.62	Thousand Oaks	0.70	40	SR 23 south (Westlake Boulevard)	Southern end of SR 23 overlap
		1.62	41	Hampshire Road
		3.02	43A	Rancho Road	Signed as exit 43B northbound
		3.11	43B	SR 23 north (Moorpark Freeway) – Fillmore, Simi Valley	Northern end of SR 23 overlap; signed as exit 43A northbound; SR 23 south exits 12A-B; Simi Valley only seen on northbound side
		4.06	44	Moorpark Road
		5.05	45	Lynn Road
		6.19	46	Ventu Park Road – Newbury Park
		7.02	47A	Rancho Conejo Boulevard, Borchard Road	Signed as exits 47A (Rancho Conejo Boulevard) and 47B (Borchard Road) northbound
		7.89	47B	Wendy Drive – Newbury Park	Signed as exit 47C northbound
	Camarillo	10.74	50	Camarillo Springs Road – Camarillo Grove County Park
		12.30	52	Santa Rosa Road, Pleasant Valley Road
		13.75	53A	Flynn Road	Northbound signage
				Dawson Drive	Southbound signage
		13.85	53B	SR 34 (Lewis Road)
		14.80	54	Carmen Drive
		15.89	55	Las Posas Road
		16.79	56	Springville Drive
		17.75	57	Central Avenue
	Oxnard	19.17	59	Del Norte Boulevard
		20.08	60	SR 1 south (Rice Avenue) / Santa Clara Avenue	Southern end of SR 1 overlap
		21.01	61	Rose Avenue
		22.01	62A	SR 232 (Vineyard Avenue) – Oxnard
		22.73	62B	Oxnard Boulevard	Former SR 1 south
		​	63A	Ventura Road	Southbound exit only
	Ventura	R23.45	63B	Johnson Drive	Signed as exit 63 northbound
		R24.65	64	Victoria Avenue – Channel Islands Harbor
		25.97	65	Telephone Road	Northbound entrance is via Main Street
		26.39	66A	SR 126 east (Santa Paula Freeway) – Santa Clarita	Signed as exit 66 southbound; southbound entrance is via exit 1C from SR 126 west; SR 126 west exit 1A
		26.72	66B	Main Street (US 101 Bus. north)	No southbound exit
		28.45	68	Seaward Avenue
		29.45	69	Vista del Mar Drive, Sanjon Road	Northbound exit and southbound entrance
		30.15	70A	California Street, Ventura Avenue
		30.91	70B	SR 33 north (Ojai Freeway) – Ojai
		31.50	71	Main Street (US 101 Bus. south)	Southbound exit and northbound entrance
	​	R32.70	72	SR 1 north (PCH) – State Beaches	Northern end of SR 1 overlap; northbound exit and southbound entrance
	​	R38.98	78	SR 1 south (PCH) – Seacliff	Southern end of SR 1 overlap
	​	R39.80	79	Mussel Shoals (Old Pacific Coast Highway)	Southbound exit and entrance
	​	41.00	81	La Conchita (West Surfside Street)	Northbound exit and entrance
	​	R43.57	83	Bates Road
Ventura–Santa Barbara county line	​	​	Northwestern end of Ventura Freeway[64]
Santa Barbara SB R0.00-90.99	Carpinteria	R0.63	84	SR 150 east – Ojai, Lake Casitas
		1.61	85	Bailard Avenue
		2.64	86A	Casitas Pass Road	Signed as exit 86 northbound; former SR 224
		3.06	86B	Linden Avenue	Southbound exit and northbound entrance
		3.77	87A	Reynolds Avenue, Santa Monica Road	Signed as exit 87 northbound
		4.34	87B	Carpinteria Avenue	Southbound exit only
	Toro Canyon	R5.28	88	Padaro Lane, Santa Claus Lane
	Summerland	R7.14	90	Padaro Lane – Summerland
		R8.26	91	Evans Avenue – Summerland
	Montecito	9.00	92	Sheffield Drive
		10.02	93	San Ysidro Road
		10.54	94A	Olive Mill Road, Coast Village Road	No northbound entrance
	Santa Barbara	11.10	94B	Hermosillo Road	Northbound exit only
		11.41	94C	Cabrillo Boulevard, Coast Village Road	No southbound entrance; signed as exit 94B southbound
		​	95	Los Patos Way (unsigned)	Southbound exit only
		12.10	95	Salinas Street	Northbound exit and entrance
		12.75	96	Milpas Street	Former SR 144; northbound exit signed as exit 96A; southbound as exits 96B and 96A
		13.49	96	Laguna Street, Garden Street – Downtown Santa Barbara	Laguna Street/Garden Street northbound exit signed as exit 96B; Garden Street southbound exit signed as exit 96C
		R14.19	97	Bath Street, Castillo Street; Santa Barbara Harbor
		R14.76	98A	Carrillo Street – Downtown Santa Barbara	Signed as exit 98 southbound
		15.26	98B	Arrellaga Street	Northbound exit and entrance
		R15.73	99A	Mission Street	Signed as exit 99 southbound
		16.05	99B	Pueblo Street	Northbound exit only
		16.55	100	Las Positas Road	Former SR 225
		17.78	101A	La Cumbre Road, Hope Avenue
		18.38	101B	SR 154 west / State Street – Cachuma Lake
	Eastern Goleta Valley	18.92	102	El Sueno Road	Northbound exit and entrance
		20.06	103	Turnpike Road
	Goleta	21.15	104A	Patterson Avenue	Signed as exit 104 southbound
		21.41	104B	SR 217 west – Airport, UCSB	Northbound exit and southbound entrance
		22.53	105	Fairview Avenue
		23.72	107	Los Carneros Road
		24.77	108	Glen Annie Road, Storke Road
		26.91	110	Winchester Canyon Road, Hollister Avenue	All ramps are via Cathedral Oaks Road
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	​	30.06	113	Dos Pueblos Canyon Road
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	​	32.84	116	El Capitan Ranch Road
	​	33.85	117	El Capitan State Beach
	​	36.62	120	Refugio Road – Refugio State Beach
	​	​	Northern end of freeway
	Gaviota	44.82	128	Mariposa Reina	Interchange
		​		Gaviota State Beach (Gaviota Beach Road)	At-grade intersection
	Gaviota Pass	46.30– 46.90	Gaviota Rest Area
		47.19	Gaviota Gorge Tunnel (northbound only)
	​	​	Southern end of freeway
	Las Cruces	R48.85	132	SR 1 north – Lompoc, Vandenberg SFB	Northern end of SR 1 overlap
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	Buellton	R56.46	139	Santa Rosa Road
		R57.12	140A	SR 246 – Lompoc, Solvang
		R57.55	140B	McMurray Road, Avenue of the Flags
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	​	62.67	146	SR 154 east / Zaca Station Road – Los Olivos, Cachuma Lake
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	Los Alamos	70.92	154	SR 135 north – Los Alamos, Vandenberg SFB
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	​	78.69	161	Solomon Summit Undercrossing
	Orcutt	82.18	164	Clark Avenue – Orcutt
83.42		166	Union Valley Parkway
Santa Maria	84.36	167	Santa Maria Way (US 101 Bus. north)
	86.59	169	Betteravia Road – Sisquoc
	87.60	170	Stowell Road
	88.60	171	SR 166 west (Main Street) – Santa Maria, Guadalupe	Southern end of SR 166 overlap
	89.69	172	Donovan Road
	90.75	173	SR 135 south (Broadway, US 101 Bus. south) – Santa Maria
San Luis Obispo SLO 0.00-R69.32	​	0.81	175	SR 166 east – Maricopa, Bakersfield	Northern end of SR 166 overlap
	Nipomo	4.85	179	Tefft Street – Nipomo
		6.43	180	Willow Road
		7.84	182	Thompson Road, Los Berros Road
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	Arroyo Grande	12.52	186	Traffic Way (US 101 Bus. north), Fair Oaks Avenue	No northbound entrance
		13.17	187A	SR 227 north (Grand Avenue, US 101 Bus. south)
		13.75	187B	Brisco Road, Halcyon Drive
	Pismo Beach	14.61	188	Oak Park Road
		15.58– 15.88	189	4th Street, Five Cities Drive	Signed as exits 189 (4th Street) and 190A (Five Cities Drive) southbound
		16.62	190	Price Street (US 101 Bus. north)	No northbound entrance; northbound signage
			190B	Hinds Avenue, Price Canyon Road	No northbound entrance; southbound signage
		16.89	191A	Wadsworth Avenue	Northbound signage; northbound entrance via Bello Street, southbound entrance via Price Street
				SR 1 south – Pismo Beach	Southbound signage; north and south entrances via Price Street
		17.76	191B	Shell Beach Road	Northbound signage
				Price Street (SR 1 south, US 101 Bus. south)	Southern end of SR 1 overlap; southbound signage
		R19.81	193	Spyglass Drive	Northbound signage
				Shell Beach Road	Southbound signage
	Avila Beach	R21.11	195	Avila Beach Drive
		R22.29	196	San Luis Bay Drive – See Canyon, Avila Beach
	​	R24.30	198	Higuera Street
	San Luis Obispo	25.91	200A	Los Osos Valley Road	Signed as exit 200 southbound
		26.83	200B	Prado Road, Elks Lane	Northbound exit and entrance
		27.50	201	SR 227 south (Madonna Road)
		28.07	202A	Marsh Street
		28.81	202B	Broad Street
		29.08	203A	Osos Street, Santa Rosa Street
		29.08	203B	SR 1 north – Morro Bay, Hearst Castle	Northern end of SR 1 overlap
		29.40	203C	California Boulevard
		29.77	203D	Grand Avenue – Cal Poly	Northbound exit and southbound entrance
		29.99	204	Monterey Street	No southbound entrance
	​	​	Northern end of freeway
	​	35.00[68]	Cuesta Pass, elevation 1,522 feet (464 m)[68]
	​	​	Southern end of freeway
	​	37.85	211	SR 58 east – Santa Margarita
	Atascadero	42.27	216A	Santa Barbara Road	Signed as exit 216 southbound
		42.90	216B	San Diego Way	Northbound exit and southbound entrance
		44.01	218A	Santa Rosa Road
		44.84	218B	Curbaril Avenue
		45.57	219	SR 41 (Morro Road)
		45.96	220A	Traffic Way (US 101 Bus. north)
		46.87	220B	San Anselmo Road
		48.33	222	Del Rio Road (US 101 Bus. south)
		49.32	223	San Ramon Road, Santa Cruz Road
	Templeton	50.64	224	Vineyard Drive (US 101 Bus. north)
		51.45	225	Las Tablas Road
		52.44	226	Main Street (US 101 Bus. south)
	Paso Robles	53.89	228	SR 46 west – Cambria, Hearst Castle	Southern end of SR 46 overlap
		55.67	229	Spring Street (US 101 Bus. north)	Northbound exit and southbound entrance; former US 101
		56.14	230	Pine Street	Southbound exit and entrance
		​	230	Paso Robles Street	Northbound exit and entrance
		56.88	231A	17th Street	Southbound exit and entrance
		57.92	231B	SR 46 east (24th Street / CR G14 west) – Fresno, Bakersfield	Northern end of SR 46 overlap; signed as exit 231 northbound
		58.76	232	Spring Street (US 101 Bus. south)	No southbound entrance; former US 101
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	San Miguel	65.08	239A	Mission Street – San Miguel	Northbound exit and southbound left entrance
		65.56	239B	10th Street	Signed as exit 239 southbound
		67.23	241A	Mission Street – San Miguel	Southbound exit and northbound entrance
	​	R67.71	241B	South Camp Roberts (Frontage Road)	Signed as exit 241 northbound; served the former south entrance to Camp Roberts
Monterey MON R0.00-101.32	​	R0.84	244	Camp Roberts (main gate)
	​	R2.15	245	East Garrison (Bradley Road)
	​	R3.35– R5.10	Camp Roberts Rest Area
	Bradley	R7.94	251	Bradley (Bradley Road)
	​	R9.67	252	CR G18 (Jolon Road) – Fort Hunter Liggett
	​	R15.47	258	Alvarado Road
	​	R17.86	260	Los Lobos Road
	​	R21.99	263	Paris Valley Road – San Ardo
	​	R29.90	271	Paris Valley Road – Lockwood
	San Lucas	R32.02	273	SR 198 east – San Lucas, Coalinga
	​	R37.31	278	Wild Horse Road
	King City	R39.77	281	First Street (US 101 Bus. north / CR G15 to CR G13)
		R40.72	282A	Canal Street
		R41.18	282B	Broadway (US 101 Bus. south / CR G13)
	​	R41.95	283	CR G14 (Jolon Road) – Fort Hunter Liggett
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	Greenfield	52.66	293	Espinosa Road (US 101 Bus. north, CR G16)	Former US 101
		53.36	294A	Oak Avenue
		53.86	294B	Walnut Avenue
		54.79	295	Thorne Road (US 101 Bus. south)	Former US 101
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	Soledad	60.40	301	Arroyo Seco Road
		61.59	302	SR 146 (US 101 Bus. north) – Soledad	Former US 101
		62.70	303	Front Street (US 101 Bus. south)
	​	64.63	305	Camphora Gloria Road
	​	66.40	307	Salinas Valley State Prison
	Gonzales	69.37	310	Gloria Road (US 101 Bus. north), Alta Street	Former US 101
		70.86	311	5th Street
		72.61	313	Old Stage Road (US 101 Bus. south)
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	Chualar	76.97	317	Chualar (Main Street)
	​	​	Northern end of freeway
	​	82.47	323	Abbott Street (US 101 Bus. north) – Spreckels	Northbound left exit and southbound left entrance; interchange
	​	​	Southern end of freeway
	Salinas	85.62	326A	Airport Boulevard
		​	326B	Fairview Avenue	Northbound exit only
		86.12	326C	Monterey Peninsula (South Sanborn Road)	Signed as exit 326B southbound
		86.82	327	SR 68 (John Street)
		87.30	328	Market Street to SR 183 – Santa Cruz
		R88.24	329	Main Street (SR 183, US 101 Bus. south)
		R89.27	330	Laurel Drive
		R91.01	331	Boronda Road (US 101 Bus. south)
	​	92.19	333	Sala Road
	​	​	Northern end of freeway
	Prunedale	95.44	336	SR 156 west / Vierra Canyon Road – Monterey Peninsula	Southern end of SR 156 overlap; interchange
		96.14	337	San Miguel Canyon Road (CR G12)	Interchange
		98.37	339	Crazy Horse Canyon Road, Echo Valley Road	Interchange
		100.39		Dunbarton Road to San Juan Road (CR G11)	Closed in 2015 after the construction of the San Juan Road interchange
San Benito SBT 0.00-R7.52	​	0.13	342	San Juan Road (CR G11) – Aromas, Watsonville	Interchange
	​	​	Southern end of freeway
	​	3.01	345	SR 156 east – San Juan Bautista, Hollister	Northern end of SR 156 overlap
	​	R4.90	347	SR 129 west – Watsonville, Santa Cruz
	​	R6.49	349	Betabel Road, Y Road
	​	​	Northern end of freeway
Santa Clara SCL R0.03-52.55	​	3.16	353	SR 25 south – Hollister, Pinnacles National Park	Interchange
	​	​	Southern end of freeway
	Gilroy	R4.94	355	Monterey Road (US 101 Bus. north)
		R6.08	356	SR 152 east (Pacheco Pass Road) / 10th Street	Southern end of SR 152 overlap
		R7.53	357	SR 152 west (Leavesley Road / CR G9) – Gilroy	Northern end of SR 152 overlap
	​	R10.27	360	Masten Avenue
	San Martin	R12.46	362	San Martin Avenue
	Morgan Hill	R15.07	365	Tennant Avenue
		R16.01	366	East Dunne Avenue
		R17.82	367	Cochrane Road (US 101 Bus. south)
	San Jose	R21.25	371	Coyote Creek Golf Drive
		R23.10	373	Bailey Avenue
		R26.78	377A	SR 85 north (West Valley Freeway) – Mountain View, Cupertino	No northbound entrance; signed as exit 377B southbound; SR 85 south exit 1A
		​	♦	SR 85 north	HOV access only; northbound exit and southbound entrance
		R27.00	377B	Silicon Valley Boulevard, Bernal Road	Signed as exit 377A southbound
		R28.61	378	Blossom Hill Road (CR G10) / Silver Creek Valley Road to SR 82	Southern end of Bayshore Freeway;[64] former SR 82
		30.10	380	Hellyer Avenue
		31.00	381	Yerba Buena Road	Southbound exit was separated from Exit 382 in 2014
		31.70	382	Capitol Expressway (CR G21)
		33.03	383	Tully Road
		34.11	385B	I-280 north / I-680 north – Downtown San Jose, Sacramento	Northbound exit and southbound entrance; southern end of Joe Colla Interchange; ramps extend over the Story Road interchange; I-680 exit 1B
		34.55	385A	Story Road	Signed as exit 385 northbound
		34.87	384	I-280 north / I-680 north – San Francisco, Downtown San Jose, Sacramento	Southbound exit and northbound entrance; northern end of Joe Colla Interchange; I-680 exit 1B
		R35.76	386A	SR 130 (Alum Rock Avenue) / Santa Clara Street
		R36.14	386B	McKee Road, Julian Street
		​	387	Mabury Road, Taylor Street	Planned interchange
		37.73	388A	Oakland Road, 13th Street	Former SR 238
		38.30	388	I-880 (Nimitz Freeway) – Oakland, Santa Cruz, Los Gatos	Signed as exits 388B (north) and 388C (south); I-880 exits 4B-C; former SR 17
		38.80	389A	Old Bayshore Highway, 4th Street	No southbound exit
		39.29	389B	Brokaw Road, First Street	Signed as exit 389 southbound
		39.93	390	SR 87 south (Guadalupe Parkway)	Southbound exit and northbound entrance; SR 87 north exit 9B
	San Jose–Santa Clara line	40.70	391	Trimble Road, De la Cruz Boulevard (CR G6)
	Santa Clara	41.98	392	San Tomas Expressway, Montague Expressway (CR G4)
		42.73	393	Great America Parkway, Bowers Avenue
	Sunnyvale	43.85	394	Lawrence Expressway (CR G2)
		44.83	395	Fair Oaks Avenue	Signed as exits 395A (north) and 395B (south) southbound
		45.68	396A	Mathilda Avenue to SR 237 east	Former SR 85
		​	—	US 101 Express Lanes	Southern end of Express Lanes
		46.13	396B	SR 237 east – Milpitas	Southbound exit and northbound entrance; SR 237 west exit 3A
		46.13	396C	SR 237 west – Mountain View	Northbound exit and southbound entrance; SR 237 east exit 3A
	Mountain View	47.01	397	Ellis Street
		47.89	398A	Moffett Boulevard, NASA Parkway	Signed as exit 398 northbound
		​	—	SR 85 Express Lanes south	Express Lanes access only; southbound exit and northbound entrance
		48.10	398B	SR 85 south – Cupertino, Santa Cruz	Southbound exit and northbound entrance; northbound exit is via exit 396C; SR 85 north exit 24B
		48.60	399A	Shoreline Boulevard	Signed as exit 399 southbound
		48.97	399B	Old Middlefield Way	Northbound exit and southbound entrance
		49.61	400A	Amphitheatre Parkway, Rengstorff Avenue	Signed as exits 400A (Amphitheatre Parkway) and 400B (Rengstorff Avenue) northbound
	Mountain View–Palo Alto line	50.32	400C	San Antonio Road	Signed as exits 400B (north) and 400C (south) southbound
	Palo Alto	52.01	402	Oregon Expressway (CR G3)
		52.17	402	Embarcadero Road
San Mateo SM 0.00-26.11	East Palo Alto	0.89	403	University Avenue (to SR 109)
	East Palo Alto–Menlo Park line	1.87	404	Willow Road (SR 114)
	Menlo Park	3.59	406	SR 84 east (Marsh Road) – Dumbarton Bridge	Southern end of SR 84 overlap
	Redwood City	5.39	408	SR 84 west (Woodside Road) / Seaport Boulevard	Northern end of SR 84 overlap
		6.62	409	Whipple Avenue
	San Carlos	​	411	Brittan Avenue	Southbound exit and entrance
		8.40	411	Holly Street, Redwood Shores Parkway
		​	412	Harbor Boulevard	Southbound exit and entrance
	Belmont	9.55	412	Marine Parkway, Ralston Avenue	Former Legislative Route 214
	San Mateo	11.15	414A	Hillsdale Boulevard – Foster City
		11.90	414B	SR 92 – Hayward, San Mateo Bridge, Half Moon Bay	SR 92 exits 13A-B
		11.90	414B	Fashion Island Boulevard	No northbound exit
		12.69	415	Kehoe Avenue	Northbound exit and entrance
		13.46	416	3rd Avenue	Former SR 92
		14.33	417A	Dore Avenue	Northbound exit only
		14.33	417	Poplar Avenue	Southbound exit and entrance
		14.69	417B	Peninsula Avenue – Burlingame	Northbound exit and entrance
	Burlingame	16.02	419A	Anza Boulevard	Northbound exit and entrance
		16.58	419B	Broadway	Signed as exit 419 southbound
	Millbrae	17.95	421	Millbrae Avenue	Signed as exit 420 southbound
	San Bruno	19.12	422	San Francisco International Airport	Southbound exit is part of exit 423A
		R20.39	423A	San Bruno Avenue
		R20.72	—	US 101 Express Lanes	Northern end of Express Lanes
			423B	I-380 west to I-280 – San Bruno	I-380 west exit 6, east exits 6A-B
	South San Francisco	R20.72	423C	North Access Road (I-380 east) – North Cargo Area	Southbound exit is part of exit 423A
		21.69	424	South Airport Boulevard
		21.92	425A	Grand Avenue – Downtown South San Francisco	No southbound entrance
		22.71	425B	Oyster Point Boulevard
		​	425C	South San Francisco (Airport Boulevard)	Southbound exit and entrance
	Brisbane	23.39	426A	Brisbane, Cow Palace (Bayshore Boulevard)	Northbound exit only
		23.66	426B	Sierra Point Parkway, Marina Boulevard	Signed as exit 426 southbound; southbound exit and entrance are located 1.2 miles (1.9 km) north of northbound exit and entrance
City and County of San Francisco SF 0.00-11.18		0.03	429A	Tunnel Avenue – Candlestick Park
		0.77	429B	Third Street – Cow Palace
		1.11	429C	Paul Avenue	No northbound entrance; signed as exit 430A southbound
		1.44	430A	I-280 – Daly City, Downtown San Francisco	Northbound exit and southbound entrance; southern end of Alemany Maze; ramps extend over the Silver Avenue interchange; I-280 north exit 54A, south exit 54
		1.77	430B	Silver Avenue	No northbound entrance
		1.98	431	I-280 south – Daly City	Southbound exit and northbound entrance; northern end of Alemany Maze; I-280 north exit 54B
		2.00	431	Alemany Boulevard, Bayshore Boulevard
		2.92	432	Cesar Chavez Street, Potrero Avenue	Cesar Chavez Street was formerly Army Street
		4.10	433A	Vermont Street	Northbound exit only
		R4.24	433B	I-80 east – Bay Bridge, Oakland	Northern end of Bayshore Freeway; southern end of Central Freeway;[64] signed as exit 433 southbound; I-80 exits 1A-B
		R4.55	433C	Ninth Street – Civic Center	Northbound exit and southbound entrance
		T5.20	434A	Duboce Avenue	Northbound exit and southbound entrance
		5.40	434B	Octavia Boulevard to Fell Street	Northbound exit and southbound entrance
		​	Northern end of Central Freeway
		​		Market Street	No left turns
		​		Geary Boulevard	No left turn from northbound US 101
		​		Broadway	No left turns from Broadway; no left turn from northbound US 101
		​		Van Ness Avenue, Lombard Street	No left turn from southbound Van Ness Avenue; no left turn from westbound Lombard Street
		​	Southern end of Presidio Parkway
		​	Southern end of freeway
		L8.59	437	Marina Boulevard, Girard Road – Marina, Presidio
		9.40	438	SR 1 south (Park Presidio Boulevard) – Golden Gate Park	Southern end of SR 1 overlap
		9.71	439	Lincoln Boulevard – View Area, Presidio, Golden Gate NRA, Fort Point	Northern end of Presidio Parkway; Lincoln Boulevard not signed northbound
Golden Gate		11.18– L0.01	Golden Gate Bridge (Southbound toll only; no state maintenance on bridge)
Marin MRN L0.00-27.63	Sausalito	0.10	H. Dana Bower Rest Area and Vista Point (northbound only); southern end of Redwood Highway
		0.32	442	Alexander Avenue
		0.89	Robin Williams Tunnel under Waldo Grade
		1.52	443	Spencer Avenue, Monte Mar Drive
		2.48	444	Rodeo Avenue (east)	Northbound exit and entrance only
				Rodeo Avenue (west; not a thru road)	Southbound exit and entrance only; connects to the Rodeo Trailhead at the Golden Gate NRA
		3.33	445A	Sausalito (Bridgeway), Marin City (Donahue Street)
		4.46	445B	SR 1 north – Mill Valley, Stinson Beach	Northern end of SR 1 overlap; Mill Valley not signed southbound
	Strawberry	4.78	446	Seminary Drive
		​		Redwood Highway Frontage Road (unsigned)	Southbound exit only
		5.70	447	SR 131 east (Tiburon Boulevard) / East Blithedale Avenue
	Corte Madera	​		Casa Buena Drive	Southbound entrance only
		7.37	449A	Paradise Drive, Tamalpais Drive	Signed as exit 449 northbound
		7.66	449B	Madera Boulevard	Southbound exit and entrance
		8.02	450A	Lucky Drive, Doherty Drive	Doherty Drive not signed northbound
	Larkspur	8.60	450B	San Anselmo, Richmond Bridge	Northbound signage
				Sir Francis Drake Boulevard	Southbound signage
	San Rafael	9.63	451A	Andersen Drive, Francisco Boulevard	Southbound exit and entrance
		10.00	451	Francisco Boulevard to I-580 east – Richmond Bridge	Northbound exit only
			451B	I-580 east – Richmond Bridge, Oakland	Southbound exit and northbound entrance; I-580 west exit 1A; former SR 17 south
		10.72	452	Central San Rafael (Second Street, Mission Avenue)
		12.19	454A	Lincoln Avenue	No northbound exit
		12.69	454B	North San Pedro Road	Signed as exit 454 northbound
		13.71	455	Freitas Parkway – Terra Linda
		14.71	456	Lucas Valley Road, Smith Ranch Road
	​	15.57	457	St. Vincent Drive, Miller Creek Road
	Novato	16.64	458	Nave Drive	Northbound signage
				Alameda del Prado	Southbound signage
		18.09	459	Ignacio Boulevard, Bel Marin Keys Boulevard, Entrada Drive – Hamilton Field	Entrada Drive, Hamilton Field not signed northbound; signed as exits 459A (Bel Marin Keys Boulevard, Hamilton Field) and 459B (Ignacio Boulevard, Entrada Drive) southbound
		18.94	460	SR 37 east / South Novato Boulevard – Napa, Vallejo	Signed as exits 460A (SR 37) and 460B (South Novato Boulevard) northbound
		R20.19	462A	Rowland Boulevard (US 101 Bus. north)
		R21.11	462B	De Long Avenue	Serves Downtown Novato
		R22.00	463	Atherton Avenue, San Marin Drive (US 101 Bus. south)
	​	26.90	467	San Antonio Road, Silveira Ranch Road
Sonoma	​	2.94	472A	Petaluma Boulevard South (US 101 Bus. north), Kastania Road
	Petaluma	3.58	472B	SR 116 east – Sonoma, Napa	Southern end of SR 116 overlap
		4.76	474	East Washington Street – Central Petaluma
		5.76	476	Old Redwood Highway, Petaluma Boulevard North (US 101 Bus. south) – Penngrove
	​	​		Stony Point Road	Southbound entrance only
	​	10.67	479	Railroad Avenue	Northbound exit only
	Cotati	12.00	481A	West Sierra Avenue	Northbound exit and southbound entrance
		12.69	481B	SR 116 west (Gravenstein Highway) – Rohnert Park, Sebastopol, Cotati	Northern end of SR 116 overlap; signed as exit 481 southbound
	Rohnert Park	13.88	483	Rohnert Park Expressway
		15.02	484A	Golf Course Drive, Wilfred Avenue	Signed as exit 484 southbound
	​	15.53	484B	Santa Rosa Avenue (US 101 Bus. north)	Northbound exit and southbound entrance
	​	16.54	485	Todd Road
	Santa Rosa	18.49	487	Yolanda Avenue, Hearn Avenue	Yolanda Avenue not signed southbound
		19.00	488A	Baker Avenue	Northbound signage
				Corby Avenue, Santa Rosa Avenue	Southbound signage
		19.66	488B	SR 12 – Sebastopol, Sonoma	SR 12 west exits 7A-B, east exit 7
		20.09	489	Third Street – Downtown Santa Rosa	Third Street not signed southbound
		20.74	490	College Avenue
		21.74	491A	Steele Lane, Guerneville Road	Signed as exit 491 southbound
		22.52	491B	Bicentennial Way	Northbound exit and southbound entrance
		22.81	492	Mendocino Avenue (US 101 Bus. south), Old Redwood Highway, Hopper Avenue	Hopper Avenue not signed northbound; Old Redwood Highway not signed southbound
	​	24.86	494	River Road – Guerneville, Calistoga
	​	25.90	495A	Fulton Road – Fulton	Closed after the reconstruction of the Airport Boulevard interchange
	​	26.33	495	Airport Boulevard, Fulton Road – Fulton
	Windsor	27.62	496	Shiloh Road
		29.35	498	Old Redwood Highway – Central Windsor
		30.67	499	Arata Lane	No northbound entrance
	Healdsburg	33.48	502	Healdsburg Avenue	Northbound signage
				Old Redwood Highway	Southbound signage
		34.55	503	Central Healdsburg (Healdsburg Avenue)	Northbound exit and southbound entrance
		34.88	504	Westside Road – Guerneville	Southbound exit and northbound entrance
		36.27	505	Dry Creek Road
	​	R38.56	507	Lytton Springs Road, Alexander Valley Road
	​	R40.03	509	Independence Lane
	Geyserville	R41.43	510	Geyserville Avenue to SR 128 east – Geyserville
		R43.37	512	SR 128 east / Canyon Road (CR C1) – Geyserville, Calistoga	Southern end of SR 128 overlap
	​	R47.85	517	Asti (Asti Road)
	​	R49.05	518	Dutcher Creek Road – Stewarts Point
	Cloverdale	R50.43	519	South Cloverdale Boulevard (US 101 Bus. north, SR 128 Bus. west)
		R51.62	520	Citrus Fair Drive
	​	R53.40	522	SR 128 west (US 101 Bus. south) – Fort Bragg, Mendocino	Northern end of SR 128 overlap
Mendocino MEN R0.10-T106.80	​	0.48	525	Geysers Road
	​	​	Northern end of freeway
	Hopland	10.89		SR 175 east – Lakeport
	​	​	Southern end of freeway
	​	19.68	544	Burke Hill Drive
	​	20.71	545	Cox-Shrader Road
	​	R21.59	546	SR 253 west – Ukiah, Boonville
	Ukiah	R23.45	548A	Talmage (SR 222)
		R24.06	548B	Gobbi Street
		R24.53	549	Perkins Street, Vichy Springs Road – Central Ukiah
		R26.16	551	North State Street – Ukiah
	​	27.41	552	Lake Mendocino Drive
	​	30.43	555A	Calpella (Moore Street, Central Avenue)
	​	30.83	555B	SR 20 east – Upper Lake, Williams	Southern end of SR 20 overlap
	​	R32.63	557	West Road – Redwood Valley
	​	​	Northern end of freeway
	​	41.06[68]	Ridgewood Summit, elevation 1,956 feet (596 m)[68]
	​	​	Southern end of freeway
	​	​	568	SR 20 west – Willits, Fort Bragg	Northern end of SR 20 overlap; former US 101 north
	​	​	573	North Main Street	Former US 101 south
	​	​	Northern end of freeway
	​	58.90	Moss Cove Rest Area (southbound only)
	Longvale	59.31		SR 162 east – Covelo, Round Valley
	​	61.82		Irvine Lodge Road – Irvine Lodge Rest Area	No left turn from US 101 south
	​	82.50	Empire Camp Rest Area (northbound only)
	​	​	Southern end of freeway
	​	R84.69	609	SR 271 north	Former US 101 north
	South Leggett	R89.57	614	South Leggett (SR 271)	Former US 101
	​	​	Northern end of freeway
	Leggett	T91.25		SR 1 south – Leggett, Fort Bragg	Former SR 208 south
	South Fork Eel River	R99.51– R100.02	Confusion Hill Bridges
	​	​	Southern end of freeway
	Reynolds	R101.89	625	SR 271	Former US 101
	Piercy	R103.81	627	Piercy (SR 271)	Former US 101
Humboldt HUM T0.00-R137.44	​	​	Northern end of freeway
	Cooks Valley	T0.08		SR 271 south – Piercy, Cooks Valley	Former US 101 south
	​	​	Southern end of freeway
	Benbow	R8.60	636	Benbow (Lake Benbow Drive)
	Garberville	R11.13	639A	Sprowel Creek Road (US 101 Bus. north) – Garberville	No northbound entrance
		R11.50	639B	Garberville, Redway (Redwood Drive)	No southbound entrance
	​	R14.31	642	Redwood Drive (US 101 Bus. south) – Redway
	​	R17.91	645	Avenue of the Giants (SR 254), Hooker Creek Road – Phillipsville	Hooker Creek Road not signed northbound; Avenue of the Giants not signed southbound
	​	R22.44	650	Miranda, Phillipsville (Maple Hills Road)
	​	25.01	653	Salmon Creek Road
	Myers Flat	27.94	656	Myers Flat (SR 254)
	​	33.22	661	Weott (Newton Road)
	​	35.70	663	South Fork, Honeydew (SR 254)
	​	39.16	667A	Avenue of the Giants (SR 254)	Southbound exit only
	​	R39.67	667	Redcrest, Holmes (Sorenson Road)
	​	R43.32	671	Pepperwood, Redcrest, Holmes (Barkdull Road)
	​	R45.90	674	Avenue of the Giants (SR 254), Jordan Road – Pepperwood	Avenue of the Giants not signed northbound; Jordan Road not signed southbound
	​	R47.95	676	Stafford Road
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	​	R51.84	679	Rio Dell, Scotia (SR 283, US 101 Bus. north)
	Rio Dell	R52.60	680	Davis Street
		R53.38	681	Wildwood Avenue (US 101 Bus. south) – Rio Dell
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	Fortuna	57.69	685	SR 36 east – Hydesville, Bridgeville
		59.50	687	Kenmar Road (US 101 Bus. north), Riverwalk Drive	Riverwalk Drive not signed southbound
		60.49	688	12th Street
		61.53	689	Main Street (US 101 Bus. south)
		62.23	690	Palmer Boulevard
	Fernbridge	63.10	691	Fernbridge, Ferndale (Fernbrige Drive to SR 211)	Northbound exit and southbound entrance
		64.30	692	Loleta, Fernbridge, Ferndale (SR 211)
	​	65.95	694	Loleta Drive
	​	68.21	696	Hookton Road – Loleta
	Humboldt Hill	70.61	698	College of the Redwoods (Tompkins Hill Road)
		72.03	699	Fields Landing (Orchard Avenue, Fields Landing Drive)
		72.88	700	King Salmon Avenue
		73.72	701	Humboldt Hill Road – Humboldt Hill
	Eureka	74.77	702	Herrick Avenue, Elk River Road
		​	Northern end of freeway
		79.17		SR 255 north (R Street) / Myrtle Avenue – Samoa
	Arcata	​	Southern end of freeway
		85.03	712	South G Street	Southbound exit and entrance
		85.83	713	SR 255 south (Samoa Boulevard) – Arcata, Samoa, Sunny Brae
		86.50	714A	14th Street – Humboldt State University	Northbound exit and southbound entrance
		86.94	714B	Sunset Avenue – Arcata, Humboldt State University	Signed as exit 714 southbound
		88.27	716A	SR 299 east – Weaverville, Redding
		88.80	716B	Giuntoli Lane, Janes Road
	McKinleyville	R90.13	718	SR 200 east (North Bank Road) / Central Avenue (US 101 Bus. north) – McKinleyville	Central Avenue not signed southbound
		R91.47	719	School Road
		R93.00	721	Murray Road
		R93.85	722	Arcata–Eureka Airport (Airport Road)
		R95.62	723	North Central Avenue (US 101 Bus. south) – McKinleyville
		R97.02	725	Crannell Road
	​	98.07	726A	Westhaven Drive	Northbound exit and southbound entrance
	​	98.36	726B	6th Avenue – Westhaven	Signed as exit 726 southbound
	Trinidad	100.71	728	Trinidad (North Westhaven Drive, Main Street)
	​	R102.90	Trinidad – Southbound Rest Area
	​	R103.37	731	Seawood Drive
	​	R105.14	Trinidad – Northbound Rest Area
	​	R106.06	734	Patricks Point Drive
	​	​	Northern end of freeway
	​	​	Southern end of freeway
	​	R126.09	753	Newton B. Drury Scenic Parkway north	Former US 101 north
Del Norte DN M0.00-46.49	​	R0.15	765	Newton B. Drury Scenic Parkway south	Former US 101 south
	​	R3.56	768	Klamath Beach Road (CR D8)
	Klamath	R4.64	769	SR 169 east – Klamath, Terwer Valley
		​	Northern end of freeway
		​		Requa Road (CR D7) / Minot Creek Road
	Crescent City	25.84		Elk Valley Road (CR D2) – Elk Valley Rancheria
		27.01		CR D3 (Northcrest Drive)
	​	​		Parkway Drive to Washington Boulevard	Northbound exit and entrance; interchange
	​	​	Southern end of freeway
	​	R27.87	791	Washington Boulevard (CR D1)	No northbound exit
	​	R30.81	794	US 199 north (Redwood Highway north) to I-5 – Grants Pass	Northbound exit and southbound entrance; US 101 south transitions onto Redwood Highway south
	​	​	Northern end of freeway
	​	​		Elk Valley Cross Road (CR D2) to US 199 – Grants Pass
	​	​		Lake Earl Drive (CR D3) – Pelican Bay State Prison
	​	36.26		SR 197 south (North Bank Road)
	​	​		Fred D. Haight Drive (CR D4)
	Smith River	39.83		Fred D. Haight Drive (CR D4) – Smith River
	​	​		Sarina Road, Ocean View Drive (CR D5)
	Smith River Rancheria	​		Mouth Smith River Road (CR D6)
	​	​		Ocean View Drive (CR D5)
	​	46.20	Agricultural Inspection Station (southbound only)
	​	46.49		US 101 north – Oregon Coast, Portland	Continuation into Oregon
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Closed/former       Concurrency terminus       Electronic toll collection       HOV only       Incomplete access       Route transition       Unopened