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  3. UGT2A2 - Wikipedia
UGT2A2 - Wikipedia
From Wikipedia, the free encyclopedia

UGT2A2
Identifiers
AliasesUGT2A2, UDP glucuronosyltransferase family 2 member A2, UDPGT 2A2
External IDsMGI: 3576095; HomoloGene: 115736; GeneCards: UGT2A2; OMA:UGT2A2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

574537

552899

Ensembl

ENSG00000271271

ENSMUSG00000029268

UniProt

Q9Y4X1

Q6PDD0

RefSeq (mRNA)

NM_001301233
NM_001105677

NM_001024148

RefSeq (protein)

NP_001019319

Location (UCSC)Chr 4: 69.59 – 69.64 MbChr 5: 87.61 – 87.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.[5][6]

Function

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.[5] UGT2A1 and UGT2A2 were recently implicated as having a role in the loss of smell symptom associated with COVID-19.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000271271 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029268 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2".
  6. ^ Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, et al. (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenetics and Genomics. 15 (10): 677–685. doi:10.1097/01.fpc.0000173483.13689.56. PMID 16141793.
  7. ^ Shelton JF, Shastri AJ, Aslibekyan S, Auton A, et al. (23andMe COVID-19 Team) (2022). "The UGT2A1/UGT2A2 locus is associated with COVID-19-related loss of smell or taste". Nature Genetics. 54 (2): 121–124. doi:10.1038/s41588-021-00986-w. medRxiv 10.1101/2021.05.28.21257993v1. PMID 35039640.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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