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CXCL6 - Wikipedia

From Wikipedia, the free encyclopedia

CXCL6

Identifiers

Aliases

CXCL6, CKA-3, GCP-2, GCP2, SCYB6, C-X-C motif chemokine ligand 6

External IDs

OMIM: 138965; MGI: 1096868; HomoloGene: 88671; GeneCards: CXCL6; OMA:CXCL6 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q13.3	Start	73,836,640 bp^[1]
Band	4q13.3	End	73,849,064 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 E1\|5 44.78 cM	Start	90,907,219 bp^[2]
Band	5 E1\|5 44.78 cM	End	90,909,483 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bronchial epithelial cell

palpebral conjunctiva

spleen

olfactory zone of nasal mucosa

cartilage tissue

islet of Langerhans

beta cell

parietal pleura

jejunal mucosa

sperm

Top expressed in

right lobe of liver

cervix

endothelial cell of lymphatic vessel

trachea

respiratory epithelium

olfactory epithelium

mandibular molars

embryo

embryo

conjunctival fornix

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	cytokine activity CXCR chemokine receptor binding heparin binding chemokine activity protein binding
Cellular component	extracellular region extracellular space
Biological process	chemotaxis cell-cell signaling chemokine-mediated signaling pathway regulation of cell population proliferation defense response to bacterium signal transduction neutrophil mediated immunity defense response positive regulation of neutrophil chemotaxis neutrophil chemotaxis neutrophil activation antimicrobial humoral immune response mediated by antimicrobial peptide cellular response to lipopolysaccharide inflammatory response immune response regulation of signaling receptor activity G protein-coupled receptor signaling pathway leukocyte homeostasis leukocyte chemotaxis response to lipopolysaccharide regulation of chemokine production regulation of neutrophil mediated killing of gram-negative bacterium
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6372


20311

Ensembl


ENSG00000124875


ENSMUSG00000029371

UniProt


P80162


P50228

RefSeq (mRNA)


NM_002993


NM_009141

RefSeq (protein)


NP_002984


NP_033167

Location (UCSC)

Chr 4: 73.84 – 73.85 Mb

Chr 5: 90.91 – 90.91 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)

Identifiers

Symbol

CXCL6

Alt. symbols

SCYB6, GCP-2, CKA-3

Other data

Chr. 4 q21

Search for
Structures	Swiss-model
Domains	InterPro

Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes.^[5]^[6] It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2.^[6] The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124875 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029371 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Proost P, Wuyts A, Conings R, Lenaerts J, Billiau A, Opdenakker G, Van Damme J (1993). "Human and bovine granulocyte chemotactic protein-2: complete amino acid sequence and functional characterization as chemokines". Biochemistry. 32 (38): 10170–7. doi:10.1021/bi00089a037. PMID 8399143.
^ ^a ^b Wuyts A, Van Osselaer N, Haelens A, Samson I, Herdewijn P, Ben-Baruch A, Oppenheim J, Proost P, Van Damme J (1997). "Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties". Biochemistry. 36 (9): 2716–23. doi:10.1021/bi961999z. PMID 9054580.
^ Modi W, Chen Z (1998). "Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids". Genomics. 47 (1): 136–9. doi:10.1006/geno.1997.5100. PMID 9465307.
^ O'Donovan N, Galvin M, Morgan J (1999). "Physical mapping of the CXC chemokine locus on human chromosome 4". Cytogenet Cell Genet. 84 (1–2): 39–42. doi:10.1159/000015209. PMID 10343098. S2CID 8087808.

Cell signaling: cytokines

By family

Chemokine

CCL	CCL1 CCL2/MCP1 CCL3/MIP1α CCL4/MIP1β CCL5/RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18/PARC/DCCK1/AMAC1/MIP4 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28
CXCL	CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17
CX3CL	CX3CL1
XCL	XCL1 XCL2

TNF

Interleukin

Type I
(grouped by
receptor
subunit)

γ chain	IL2/IL15 IL4/IL13 IL7 IL9 IL21
β chain	IL3 IL5 GMCSF
IL6 like/gp130	IL6 IL11 IL27 IL30 IL31 +non IL OSM LIF CNTF CTF1
IL12 family/IL12RB1	IL12 IL23 IL27 IL35
Other	IL14 IL16 IL32 IL34

Type II

IL10 family

IL10/IL22
IL19
IL20
IL24
IL26
Interferon type III
- IL28/IFNL2+3
- IL29/IFNL1

Interferon

I	IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IFNK IFNW1
II	IFNG

Ig superfamily

IL17 family

IL17/IL25 (IL17A)

Other

By function/
cell

proinflammatory cytokine
- IL1
- TNFA

Monokine
Lymphokine
- T_h1
  - IFNγ
  - TNFβ
- T_h2
  - IL4
  - IL5
  - IL6
  - IL10
  - IL13

Chemokine receptor modulators

CCR1	Agonists: CCL4 (MIP-1β) CCL5 (RANTES) CCL6 CCL9 (CCL10) CCL14 CCL15 CCL16 CCL23
CCR2	Agonists: CCL2 CCL8 CCL12 CCL16 NAMs: Cenicriviroc (TAK-652, TBR-652)
CCR3	Agonists: CCL5 (RANTES) CCL7 CCL11 CCL13 CCL15 CCL18 CCL24 CCL26 CCL28
CCR4	Agonists: CCL3 (MIP-1α) CCL5 (RANTES) CCL17 CCL22 Antibodies: Mogamulizumab (against CCR4)
CCR5	Agonists: CCL3 (MIP-1α) CCL4 (MIP-1β) CCL5 (RANTES) CCL8 CCL11 CCL13 CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140
CCR6	Agonists: CCL20
CCR7	Agonists: CCL19 CCL21
CCR8	Agonists: CCL1 CCL16
CCR9	Agonists: CCL25
CCR10	Agonists: CCL27 CCL28
CCR11	Agonists: CCL19 CCL21 CCL25
Ungrouped	Antibodies: Bertilimumab (against CCL11) Carlumab (against CCL2)

CXC

CXCR1 (IL-8Rα)	Agonists: CXCL6 Emoctakin Interleukin-8 (CXCL8, GCP-1) Antagonists: Navarixin NAMs: Ladarixin Reparixin (repertaxin)
CXCR2 (IL-8Rβ)	Agonists: CXCL1 (MGSA) CXCL2 CXCL3 CXCL5 CXCL6 CXCL7 Emoctakin Garnocestim Interleukin-8 (CXCL8, GCP-1) Antagonists: Danirixin Elubrixin Navarixin NAMs: Ladarixin Reparixin (repertaxin)
CXCR3	Agonists: CXCL4 (PF4) CXCL9 (MIG) CXCL10 (IP-10) CXCL11 (I-TAC) Iroplact Antibodies: Eldelumab (against CXCL10)
CXCR4	Agonists: MIF SDF-1 (CXCL12) Ubiquitin Antagonists: Mavorixafor Plerixafor (AMD3100) Antibodies: Ulocuplumab (against CXCR4)
CXCR5	Agonists: CXCL13
CXCR6	Agonists: CXCL16
CXCR7	Agonists: Conolidine CXCL11 (I-TAC) CCX771 LIH383 RTI-5152-12 SDF-1 (CXCL12) VUF15485 PAMs: Plerixafor (AMD3100)

C (XC)

XCR1	Agonists: Lymphotactin-α (XCL1) Lymphotactin-β (XCL2) Antibodies: Pateclizumab

CX3C

CX3CR1	Agonists: Fractalkine (CX3CL1)

Others

CCBP2	Agonists: CC (β) chemokines
CMKLR1	Agonists: Chemerin Resolvin E1

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