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CYP107 family - Wikipedia

From Wikipedia, the free encyclopedia

Cytochrome P450, family 107, also known as CYP107, is a cytochrome P450 monooxygenase family in bacteria,^[2]^[1] found to be conserved and highly populated in Streptomyces and Bacillus species.^[3] The first gene identified in this family is Cytochrome P450 eryF (CYP107A1) from Saccharopolyspora erythraea.^[4] Many enzymes of this family are involved in the synthesis of macrolide antibiotics.^[2]^[5] The members of this family are widely distributed in Alphaproteobacteria, cyanobacterial, Mycobacterium, Bacillota, and Streptomyces species, which may be due to horizontal gene transfer driven by selection pressure.^[6]

References

^ ^a ^b Nebert, DW; Nelson, DR; Coon, MJ; Estabrook, RW; Feyereisen, R; Fujii-Kuriyama, Y; Gonzalez, FJ; Guengerich, FP; Gunsalus, IC; Johnson, EF (January 1991). "The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature". DNA and Cell Biology. 10 (1): 1–14. doi:10.1089/dna.1991.10.1. PMID 1991046.
^ ^a ^b Padayachee, T; Lamb, DC; Nelson, DR; Syed, K (1 December 2023). "Structure-Function Analysis of the Biotechnologically Important Cytochrome P450 107 (CYP107) Enzyme Family". Biomolecules. 13 (12): 1733. doi:10.3390/biom13121733. PMC 10741444. PMID 38136604.
^ Mnguni, FC; Padayachee, T; Chen, W; Gront, D; Yu, JH; Nelson, DR; Syed, K (7 July 2020). "More P450s Are Involved in Secondary Metabolite Biosynthesis in Streptomyces Compared to Bacillus, Cyanobacteria, and Mycobacterium". International Journal of Molecular Sciences. 21 (13): 4814. doi:10.3390/ijms21134814. PMC 7369989. PMID 32646068.
^ Weber, JM; Leung, JO; Swanson, SJ; Idler, KB; McAlpine, JB (5 April 1991). "An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea". Science. 252 (5002): 114–7. Bibcode:1991Sci...252..114W. doi:10.1126/science.2011746. PMID 2011746.
^ Kim, V; Lim, YR; Lee, I; Lee, JH; Han, S; Pham, TV; Kim, H; Lee, R; Kang, LW; Kim, D (15 October 2020). "Structural insights into CYP107G1 from rapamycin-producing Streptomyces rapamycinicus". Archives of Biochemistry and Biophysics. 692: 108544. doi:10.1016/j.abb.2020.108544. PMID 32822639. S2CID 221236896.
^ Nzuza, N; Padayachee, T; Syed, PR; Kryś, JD; Chen, W; Gront, D; Nelson, DR; Syed, K (2021-05-24). "Ancient Bacterial Class Alphaproteobacteria Cytochrome P450 Monooxygenases Can Be Found in Other Bacterial Species". International Journal of Molecular Sciences. 22 (11): 5542. doi:10.3390/ijms22115542. PMC 8197338. PMID 34073951.

v t e Cytochromes, oxygenases: cytochrome P450 (Most belong to EC 1.14)
CYP1	A1 A2 A5 B1
CYP2	A6 A7 A13 B6 C8 C9 C18 C19 D6 E1 F1 J2 R1 S1 U1 W1
CYP3 (CYP3A)	A4 A5 A7 A37 A43
CYP4	A11 A22 B1 F2 F3 F8 F11 F12 F22 V2 X1 Z1
CYP5-20	CYP5 (A1) CYP6 (G1, M2) CYP7 (A1, B1) CYP8 (A1, B1) CYP9 CYP10 CYP11 (A1, A2, B1, B2, B3, C1) CYP12 CYP13 CYP14 CYP15 CYP16 CYP17 (A1) CYP18 CYP19 (A1) CYP20 (A1)
CYP21-49	CYP21 (A2) CYP22 (A1) CYP23 CYP24 (A1) CYP25 CYP26 (A1, B1, C1) CYP27 (A1, B1, C1) CYP28 (A1) CYP29 CYP35 (B1) CYP39 (A1) CYP46 (A1)
CYP51-69	CYP51 (A1, F1) CYP52 CYP53 A1 CYP55 A1 CYP56 A1 CYP61
CYP71-99	CYP71 (C1, C2, C3, C4, Z6, AJ4, AV1, BA1) CYP72A1 CYP73A1 CYP74 (D1) CYP75 (A1, B1) CYP76 (B6, M7) CYP79 (A1, A2, B1, B2, B3, D1, D2, D3, D4) CYP80 (A1, B1, G2) CYP81 (E1, E3, E7, E9) CYP88D6 CYP90C1 CYP93E1 CYP97C1 CYP99A3
CYP101-281	CYP101A1 CYP102A1 CYP105 A1 D7 CYP106A2 CYP107 A1 G1 CYP109 B1 E1 CYP111 CYP113A1 CYP119A1 CYP123 CYP125A1 CYP139 CYP147 CYP152 A1 B1 CYP154C3 CYP158A CYP161C CYP170 A1 B1 CYP176A1 CYP183A CYP197 CYP199A2 CYP255A
CYP301-499	CYP303A1 CYP305 M2 Halloween genes ( CYP302A1, CYP306A1, CYP307A1, CYP307A2, CYP314A1, CYP315A1) CYP318A1
CYP501-699	CYP503 CYP504B1
CYP701-999	CYP704B22 CYP710 CYP720A1

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