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Flag Counter
  2. World Encyclopedia
  3. Ceftezole - Wikipedia
Ceftezole - Wikipedia
From Wikipedia, the free encyclopedia
Ceftezole
Clinical data
ATC code
Identifiers
  • (6R,7R)-8-oxo-7-{[2-(tetrazol-1-yl)acetyl]amino}-
    3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-
    1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.113.941 Edit this at Wikidata
Chemical and physical data
FormulaC13H12N8O4S3
Molar mass440.47 g·mol−1
3D model (JSmol)
  • O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)Cn3nnnc3)CSc4nncs4)C(=O)O
  • InChI=1S/C13H12N8O4S3/c22-7(1-20-4-14-18-19-20)16-8-10(23)21-9(12(24)25)6(2-26-11(8)21)3-27-13-17-15-5-28-13/h4-5,8,11H,1-3H2,(H,16,22)(H,24,25)/t8-,11-/m1/s1 checkY
  • Key:DZMVCVMFETWNIU-LDYMZIIASA-N checkY

Ceftezole (or ceftezol) is a semisynthetic first-generation cephalosporin antibiotic.[1]

Ceftezole binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.[citation needed]

Ceftezole is having (1,3,4-thiadiazol-2-ylsulfanyl)methyl and [2-(1H-tetrazol-1-yl)acetamido side groups located at positions 3 and 7 respectively. It is a cephalosporin and a member of thiadiazoles.[citation needed]

References

  1. ^ Berger SA (2021). "Ceftezole". GIDEON Guide to Antimicrobial Agents. Los Angeles: Gideon Informatics, Incorporated. p. 301. ISBN 978-1-4988-2958-8.

Note

  • Media related to Ceftezole at Wikimedia Commons


Stub icon

This systemic antibiotic-related article is a stub. You can help Wikipedia by adding missing information.

Sunting pranala
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