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  3. Fotemustine - Wikipedia
Fotemustine - Wikipedia
From Wikipedia, the free encyclopedia
Fotemustine
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  • AU: D
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  • (RS)-diethyl (1-{[(2-chloroethyl)(nitroso)carbamoyl]amino}
    ethyl)phosphonate
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FormulaC9H19ClN3O5P
Molar mass315.69 g·mol−1
3D model (JSmol)
  • O=P(OCC)(OCC)C(NC(=O)N(N=O)CCCl)C
  • InChI=1S/C9H19ClN3O5P/c1-4-17-19(16,18-5-2)8(3)11-9(14)13(12-15)7-6-10/h8H,4-7H2,1-3H3,(H,11,14) checkY
  • Key:YAKWPXVTIGTRJH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fotemustine is a nitrosourea alkylating agent used in the treatment of metastatic melanoma. It is available in Europe but has not been approved by the United States FDA.[1] A study[2] has shown that fotemustine produces improved response rates but does not increase survival (over dacarbazine in the treatment of disseminated cutaneous melanoma. Median survival was 7.3 months with fotemustine versus 5.6 months with DTIC (P=.067). There was also toxicity prevalence in fotemustine arm. The main toxicity was grade 3 to 4 neutropenia (51% with fotemustine v 5% with DTIC) and thrombocytopenia (43% v 6%, respectively).

  1. ^ Menaa, Farid (2013). "Latest Approved Therapies for Metastatic Melanoma: What Comes Next?". Journal of Skin Cancer. 2013: 1–10. doi:10.1155/2013/735282. PMC 3595667. PMID 23533766.
  2. ^ Avril MF, Aamdal S, Grob JJ, Hauschild A, Mohr P, Bonerandi JJ, Weichenthal M (March 2004). "Fotemustine Compared With Dacarbazine in Patients With Disseminated Malignant Melanoma: A Phase III Study". Journal of Clinical Oncology. 22 (6): 1118–25. doi:10.1200/JCO.2004.04.165. PMID 15020614.
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