KRT78

KRT78
Identifiers
Aliases	KRT78, CK-78, K5B, K78, Kb40, keratin 78
External IDs	OMIM: 611159; MGI: 1917529; HomoloGene: 65261; GeneCards: KRT78; OMA:KRT78 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,849,092 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,862,722 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; oral cavity; ; mucosa of pharynx; ; amniotic fluid; ; skin of leg; ; body of tongue; ; gums; ; skin of abdomen; ; gingival epithelium; ; testicle;
	Top expressed in
	esophagus; ; lip; ; skin of external ear; ; condyle; ; conjunctival fornix; ; fossa; ; stomach; ; skin of back; ; cornea; ; molar;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity;
Cellular component	intermediate filament; keratin filament; extracellular exosome; extracellular space; cytosol;
Biological process	keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
	196374
	332131
	ENSG00000170423
	ENSMUSG00000050463
	Q8N1N4
	n/a
	NM_001300814; NM_173352
	NM_212487
	NP_001287743; NP_775487
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type II cytoskeletal 78 is a protein that in humans is encoded by the KRT78 gene.^[5]^[6]

This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170423 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050463 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
^ ^a ^b "Entrez Gene: KRT78 keratin 78".

Coulombe PA, Omary MB (2002). "'Hard' and 'soft' principles defining the structure, function and regulation of keratin intermediate filaments". Curr. Opin. Cell Biol. 14 (1): 110–22. doi:10.1016/S0955-0674(01)00301-5. PMID 11792552.
Mischke D, Wild G (1987). "Polymorphic keratins in human epidermis". J. Invest. Dermatol. 88 (2): 191–7. doi:10.1111/1523-1747.ep12525329. PMID 2433356.
Rogers MA, Winter H, Langbein L, et al. (2000). "Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain". J. Invest. Dermatol. 114 (3): 464–72. doi:10.1046/j.1523-1747.2000.00910.x. PMID 10692104.
Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18". J. Cell Sci. 114 (Pt 14): 2569–75. doi:10.1242/jcs.114.14.2569. PMID 11683385.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hesse M, Zimek A, Weber K, Magin TM (2004). "Comprehensive analysis of keratin gene clusters in humans and rodents". Eur. J. Cell Biol. 83 (1): 19–26. doi:10.1078/0171-9335-00354. hdl:11858/00-001M-0000-0012-EE54-6. PMID 15085952.
Rogers MA, Edler L, Winter H, et al. (2005). "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13". J. Invest. Dermatol. 124 (3): 536–44. doi:10.1111/j.0022-202X.2004.23530.x. PMID 15737194.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170423 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050463 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16831889-5] Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.

[entrez-6] "Entrez Gene: KRT78 keratin 78".

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Epstein Files Full PDF

References

Further reading