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MYO1E - Wikipedia

From Wikipedia, the free encyclopedia

MYO1E

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2XMF

Identifiers

Aliases

MYO1E, FSGS6, HuncM-IC, MYO1C, myosin IE

External IDs

OMIM: 601479; MGI: 106621; HomoloGene: 55864; GeneCards: MYO1E; OMA:MYO1E - orthologs

Gene location (Human)

Chr.	Chromosome 15 (human)^[1]

Band	15q22.2	Start	59,132,434 bp^[1]
Band	15q22.2	End	59,372,871 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9 D\|9 39.41 cM	Start	70,114,632 bp^[2]
Band	9 D\|9 39.41 cM	End	70,307,048 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

sural nerve

gallbladder

tibial arteries

rectum

stromal cell of endometrium

skin of leg

Descending thoracic aorta

mucosa of transverse colon

ascending aorta

Top expressed in

lumbar spinal ganglion

mesenteric lymph nodes

calvaria

left colon

cumulus cell

tail of embryo

duodenum

epithelium of stomach

lacrimal gland

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding calmodulin binding actin filament binding microfilament motor activity protein binding phosphatidylinositol binding actin binding cytoskeletal motor activity ATP binding lipid binding
Cellular component	cytoplasm cell-cell junction clathrin-coated endocytic vesicle adherens junction cell junction brush border actin cytoskeleton extracellular exosome cytoskeleton cytoplasmic vesicle clathrin-coated vesicle myosin complex
Biological process	hemopoiesis endocytosis glomerular visceral epithelial cell development glomerular basement membrane development kidney development post-embryonic hemopoiesis in utero embryonic development actin filament-based movement vasculogenesis nitrogen compound metabolic process glomerular filtration platelet-derived growth factor receptor signaling pathway metabolism
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


4643


71602

Ensembl


ENSG00000157483


ENSMUSG00000032220

UniProt


Q12965


E9Q634

RefSeq (mRNA)


NM_004998


NM_181072 NM_025612

RefSeq (protein)


NP_004989


NP_851417

Location (UCSC)

Chr 15: 59.13 – 59.37 Mb

Chr 9: 70.11 – 70.31 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.^[5]^[6]

Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. ^[7]

The MYO1E gene was included in several genetic signatures for cancer prognosis.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157483 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032220 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, et al. (September 1996). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–439. doi:10.1006/geno.1996.0488. PMID 8884266.
^ "Entrez Gene: MYO1E myosin IE".
^ McConnell RE, Tyska MJ (July 2010). "Leveraging the membrane - cytoskeleton interface with myosin-1". Trends in Cell Biology. 20 (7): 418–426. doi:10.1016/j.tcb.2010.04.004. PMC 2897960. PMID 20471271.
^ Chicco D, Alameer A, Rahmati S, Jurman G (November 2022). "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining. 15 (1): 28. doi:10.1186/s13040-022-00312-y. eISSN 1756-0381. PMC 9632055. PMID 36329531.

External links

Overview of all the structural information available in the PDB for UniProt: E9Q634 (Mouse Unconventional myosin-Ie) at the PDBe-KB.

Proteins of the cytoskeleton

Human

Microfilaments
and ABPs

Myofilament

Actins	A1 A2 B C1 G1 G2
Myosins	I MYO1A MYO1B MYO1C MYO1D MYO1E MYO1F MYO1G MYO1H) II MYH1 MYH2 MYH3 MYH4 MYH6 MYH7 MYH7B MYH8 MYH9 MYH10 MYH11 MYH13 MYH14 MYH15 MYH16 III MYO3A MYO3B V MYO5A MYO5B MYO5C VI MYO6 VII MYO7A MYO7B IX MYO9A MYO9B X MYO10 XV MYO15A XVIII MYO18A MYO18B LC MYL1 MYL2 MYL3 MYL4 MYL5 MYL6 MYL6B MYL7 MYL9 MYLIP MYLK MYLK2 MYLL1
Other	Tropomodulin 1 2 3 4 Troponin T 1 2 3 C 1 2 I 1 2 3 Tropomyosin 1 2 3 4 Actinin 1 2 3 4 Arp2/3 complex actin depolymerizing factors Cofilin 1 2 Destrin Gelsolin Profilin 1 2 Titin

Other

Intermediate
filaments

Type 1/2
(Keratin,
Cytokeratin)

Epithelial keratins (soft alpha-keratins)	type I/chromosome 17 9 10 12 13 14 15 16 17 19 20 chromosome 12 18 none 21 type II/chromosome 12 1 2A 3 4 5 6A 6B 6C 7 8
Hair keratins (hard alpha-keratins)	type I/chromosome 17 31 32 33A 33B 34 35 36 37 38 type II/chromosome 12 81 82 83 84 85 86
Ungrouped alpha	chromosome 17 23 24 25 26 27 28 39 40 chromosome 12 71 72 73 74 75 76 77 78 79 80
Not alpha	Beta-keratin

Type 3

Type 4

Type 5

Microtubules
and MAPs

Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBB TUBB1 TUBB2A TUBB2B TUBB2C TUBB3 TUBB4 TUBB4Q TUBB6 TUBB8 TUBG1 TUBG2 TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6 TUBD1 TUBE1
MAPs	EB1 EB2 EB3 MAP1A MAP1B MAP2 MAP4
Kinesins	KIF1A KIF1B KIF2A KIF2C KIF3B KIF3C KIF4A KIF4B KIF5A KIF5B KIF5C KIF6 KIF7 KIF9 KIF11 KIF12 KIF13A KIF13B KIF14 KIF15 KIF16B KIF17 KIF18A KIF18B KIF19 KIF20A KIF20B KIF21A KIF21B KIF22 KIF23 KIF24 KIF25 KIF26A KIF26B KIF27 KIFC1 KIFC2 KIFC3
Dyneins	axonemal: DNAH1 DNAH2 DNAH3 DNAH5 DNAH6 DNAH7 DNAH8 DNAH9 DNAH10 DNAH11 DNAH12 DNAH13 DNAH14 DNAH17 DNAI1 DNAI2 DNALI1 DNAL1 DNAL4 cytoplasmic: DYNC1H1 DYNC2H1 DYNC1I1 DYNC1I2 DYNC1LI1 DYNC1LI2 DYNC2LI1 DYNLL1 DYNLL2 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3
Microtubule organising proteins	CAMSAP1 CAMSAP2 CAMSAP3 Centrin 1 Centrin 2 Centrin 3 PCM1
Microtubule severing proteins	Katanin Spastin
Other	Tau protein Dynactin DCTN1 Stathmin Tektin TEKT1 TEKT2 TEKT3 TEKT4 TEKT5 Dynamin DNM1 DNM2 DNM3