mir-278 microRNA precursor family

From Wikipedia, the free encyclopedia

mir-278
Identifiers
Symbol	mir-278
Rfam	RF00729
miRBase family	3
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-278 microRNA is a short RNA molecule belonging to a class of molecules referred to as microRNAs. These function to regulate the expression levels of other genes by several mechanisms, primarily binding to their target at its 3'UTR.

Mis- and altered expression in Drosophila

miR-278 affects energy metabolism in the Drosophila melanogaster species. Elevated insulin production has been observed in miR-278 mutants, due to insulin resistance in the absence of this microRNA. miR-278 is now known to act through regulation of the expanded gene transcript, and most likely through further miR-278 targets as well.^[1]

Misexpression in the developing eye has been found to result in overgrowth, partially through apoptotic inhibition.^[2] There is a single base substitution which blocks the gain-of-function phenotype, indicating the acquisition of novel functions by misexpressed miRNAs which bring about unscheduled cell proliferation in vivo. This is reflective of a microRNA potential in the promotion of tumour formation.

References

^ Teleman AA, Maitra S, Cohen SM (2006). "Drosophila lacking microRNA miR-278 are defective in energy homeostasis". Genes Dev. 20 (4): 417–22. doi:10.1101/gad.374406. PMC 1369043. PMID 16481470.
^ Nairz K, Rottig C, Rintelen F, Zdobnov E, Moser M, Hafen E (2006). "Overgrowth caused by misexpression of a microRNA with dispensable wild-type function". Dev Biol. 291 (2): 314–24. doi:10.1016/j.ydbio.2005.11.047. PMID 16443211.

External links

Page for mir-278 microRNA precursor family at Rfam

v t e miRNA precursor families
1-100	1 2 3 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 25 26 28 29 30 31 32 33 34 42 46/47/281 48 52 58 61 62 67 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 154 155 156 160 166 172 181 184 185 186 187 188 190 191 192/215 193 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 281 282 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 351 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401-500	403 408 423 425 430 431 432 433 434 444 448 449 451 452 454 455 474 484 488 489 491 492 497 498 500
501-600	503 504 505 506 529 535 541 542 544 548 549 550 552 558 562 569 572 575 580 584 589 590 592 598
601+	601 605 612 615 612 612 624 625 632 633 636 638 650 652 657 661 663 671 672 675 708 711 720 744 764 765 767 786 802 824 828 854 872 873 874 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

This genetics article is a stub. You can help Wikipedia by expanding it.

Categories:

Hidden category:

All stub articles

Mis- and altered expression in Drosophila

See also

References

Further reading

External links