mir-618 microRNA precursor family

From Wikipedia, the free encyclopedia

mir-618
Identifiers
Symbol	mir-618
Rfam	RF01034
miRBase family	MIPF0000553
Other data
RNA type	microRNA
Domain(s)	Eukaryota
PDB structures	PDBe

mir-618 microRNA is a short non-coding RNA molecule belonging both to the family of microRNAs and to that of small interfering RNAs (siRNAs). MicroRNAs function to regulate the expression levels of other genes by several mechanisms, whilst siRNAs are involved primarily with the RNA interference (RNAi) pathway.

miR-618 in oestrogen treatment

Decreased levels of miR-618 have been observed in estradiol(E2)-stimulated MCF-7 breast cancer cells following hormone deprivation. Intracellular miR-618 levels can be regulated by E2 via the ER2 receptor. This points towards a possible of this miRNA, amongst others, in modulating the final gene responses to the oestrogen family of hormones in breast cancer cells.^[1]

Microgravity effects in lymphoblastoid cells

Altered expression of miR-618 has been seen in the human lymphoblastoid TK6 cell line, with downregulation following stress-related stimulated microgravity in TK6 cells. This further influences several genes involved in regulation of the NF-κB-related pathway network.^[2]

References

^ Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R, Luo S, Schroth GP, Seifert M, Zinser C, Chiusano ML, Traini A, De Bortoli M, Weisz A (May 2010). "Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs". The American Journal of Pathology. 176 (5): 2113–30. doi:10.2353/ajpath.2010.090837. PMC 2861078. PMID 20348243.
^ Mangala LS, Zhang Y, He Z, Emami K, Ramesh GT, Story M, Rohde LH, Wu H (September 2011). "Effects of simulated microgravity on expression profile of microRNA in human lymphoblastoid cells". The Journal of Biological Chemistry. 286 (37): 32483–90. doi:10.1074/jbc.M111.267765. PMC 3173213. PMID 21775437.

External links

Page for mir-618 microRNA precursor family at Rfam

v t e miRNA precursor families
1-100	1 2 3 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 25 26 28 29 30 31 32 33 34 42 46/47/281 48 52 58 61 62 67 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 154 155 156 160 166 172 181 184 185 186 187 188 190 191 192/215 193 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 281 282 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 351 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401-500	403 408 423 425 430 431 432 433 434 444 448 449 451 452 454 455 474 484 488 489 491 492 497 498 500
501-600	503 504 505 506 529 535 541 542 544 548 549 550 552 558 562 569 572 575 580 584 589 590 592 598
601+	601 605 612 615 612 612 624 625 632 633 636 638 650 652 657 661 663 671 672 675 708 711 720 744 764 765 767 786 802 824 828 854 872 873 874 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

This genetics article is a stub. You can help Wikipedia by expanding it.

Categories:

Hidden category:

All stub articles

miR-618 in oestrogen treatment

Microgravity effects in lymphoblastoid cells

See also

References

Further reading

External links