mir-632 microRNA precursor family

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mir-632
Identifiers
Symbol	mir-632
Rfam	RF01010
miRBase family	MIPF0000527
Other data
RNA type	microRNA
Domain(s)	Eukaryota;
PDB structures	PDBe

In molecular biology mir-632 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

miR-632 and MDS

miR-632 has been identified as one of three key miRNAs associated with the anti-ageing myelodysplastic syndromes (MDS). In particular, its levels show high discrimination between MDS and normal controls, and expression is decreased in MDS.^[1] In this way it can be used as a potential diagnostic marker for MDS.

DNAJB6 protein

miR-632 targets the coding region of the DNAJB6 protein, a member of the Heat Shock Protein 40 (HSP40) family which shows constitutive expression. DNAJB6 is known to be a negative regulator of tumour progression in breast cancer and its levels are compromised in advanced tumour progression. miR-632 has been linked to be downregulation of DNAJB6 and is capable of silencing both spliced variants of this protein.^[2] It is currently unknown whether miR-632 may be just one of many negative regulators controlling DNAJB6 levels.

References

^ Erdogan B, Facey C, Qualtieri J, Tedesco J, Rinker E, Isett RB, et al. (2011). "Diagnostic microRNAs in myelodysplastic syndrome". Exp Hematol. 39 (9): 915–926.e2. doi:10.1016/j.exphem.2011.06.002. PMID 21703983.
^ Mitra A, Rostas JW, Dyess DL, Shevde LA, Samant RS (2012). "Micro-RNA-632 downregulates DNAJB6 in breast cancer". Lab Invest. 92 (9): 1310–7. doi:10.1038/labinvest.2012.87. PMC 3660857. PMID 22710984.

External links

Page for mir-632 microRNA precursor family at Rfam

v t e miRNA precursor families
1-100	1 2 3 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 25 26 28 29 30 31 32 33 34 42 46/47/281 48 52 58 61 62 67 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 154 155 156 160 166 172 181 184 185 186 187 188 190 191 192/215 193 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 281 282 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 351 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401-500	403 408 423 425 430 431 432 433 434 444 448 449 451 452 454 455 474 484 488 489 491 492 497 498 500
501-600	503 504 505 506 529 535 541 542 544 548 549 550 552 558 562 569 572 575 580 584 589 590 592 598
601+	601 605 612 615 612 612 624 625 632 633 636 638 650 652 657 661 663 671 672 675 708 711 720 744 764 765 767 786 802 824 828 854 872 873 874 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

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miR-632 and MDS

DNAJB6 protein

See also

References

External links