mir-BHRF1-1 microRNA precursor family

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mir-BHRF1-1 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-BHRF1-1
Identifiers
Symbol	mir-BHRF1-1
Rfam	RF00365
Other data
RNA type	Gene; miRNA
Domain(s)	Viruses
GO	GO:0035195 GO:0035068
SO	SO:0001244
PDB structures	PDBe

The mir-BHRF1-1 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus) and Cercopithicine herpesvirus 15. In Epstein–Barr virus, mir-BHRF1-1 is found in the 5' UTR of the BHRF1 (Bam HI fragment H rightward open reading frame 1) gene, which is known to encode a distant Bcl-2 homolog. The mature sequence is excised from the 5' arm of the hairpin.^[1] Two other miRNA precursors were found in this reading frame, namely Mir-BHRF1-2 and Mir-BHRF1-3.^[1]

BHRF-1-1 miRNA is thought to operate as part of a 'miRNA cluster' with two other microRNAs also found in the Epstein–Barr virus genome.^[2] BHRF-1-1 has been shown to be expressed in latency-III infected lymphoblasts.^[3]

References

^ ^a ^b Pfeffer S, Zavolan M, Grässer FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T (April 2004). "Identification of virus-encoded microRNAs". Science. 304 (5671): 734–6. doi:10.1126/science.1096781. PMID 15118162. S2CID 25287167.
^ Feederle R, Haar J, Bernhardt K, Linnstaedt SD, Bannert H, Lips H, Cullen BR, Delecluse HJ (October 2011). "The members of an Epstein-Barr virus microRNA cluster cooperate to transform B lymphocytes". Journal of Virology. 85 (19): 9801–10. doi:10.1128/JVI.05100-11. PMC 3196389. PMID 21752900.
^ Xing L, Kieff E (September 2007). "Epstein-Barr virus BHRF1 micro- and stable RNAs during latency III and after induction of replication". Journal of Virology. 81 (18): 9967–75. doi:10.1128/JVI.02244-06. PMC 2045418. PMID 17626073.

External links

Page for mir-BHRF1-1 microRNA precursor family at Rfam

v t e miRNA precursor families
1-100	1 2 3 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 25 26 28 29 30 31 32 33 34 42 46/47/281 48 52 58 61 62 67 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 154 155 156 160 166 172 181 184 185 186 187 188 190 191 192/215 193 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 281 282 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 351 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401-500	403 408 423 425 430 431 432 433 434 444 448 449 451 452 454 455 474 484 488 489 491 492 497 498 500
501-600	503 504 505 506 529 535 541 542 544 548 549 550 552 558 562 569 572 575 580 584 589 590 592 598
601+	601 605 612 615 612 612 624 625 632 633 636 638 650 652 657 661 663 671 672 675 708 711 720 744 764 765 767 786 802 824 828 854 872 873 874 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

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