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mir-48 microRNA is a microRNA which is found in nematodes, in which it controls developmental timing. It acts in the heterochronic pathway, where it controls the timing of cell fate decisions in the vulva and hypodermis during larval development.^[1]

Gene structure and location

Along with mir-241, mir-48 is found in the lin-58 allele between the genes hum-5 and unc-76.^[2] It is related to (at least) three other miRNAs (let-7,mir-84 and mir-241), with which it shares eight identical bases at the 5′ end of the mature miRNA.^[3]

Function

mir-48, along with let-7, mir-84 and mir-241, controls developmental timing events in C. elegans proliferative seam cells and hypodermal syncytial cells. Double mutations in mir-48 and mir-214 result in worms displaying a retarded cell lineage phenotype; extra seam cells are observed in the L3 and L4 developmental stages when compared to wild-type worms. It is thought that the extra cells arise due to mutant miRNAs being unable to repress the gene hbl-1, which also plays a role in developmental timing.^[3]

References

^ Li, M.; Jones-Rhoades, M. W.; Lau, N. C.; Bartel, D. P.; Rougvie, A. E. (2005). "Regulatory Mutations of mir-48, a C. Elegans let-7 Family MicroRNA, Cause Developmental Timing Defects". Developmental Cell. 9 (3): 415–422. doi:10.1016/j.devcel.2005.08.002. PMID 16139229.
^ Lau, N. C.; Lim, L. P.; Weinstein, E. G.; Bartel, D. P. (2001). "An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans". Science. 294 (5543): 858–862. Bibcode:2001Sci...294..858L. doi:10.1126/science.1065062. PMID 11679671. S2CID 43262684.
^ ^a ^b Abbott, A. L.; Alvarez-Saavedra, E.; Miska, E. A.; Lau, N. C.; Bartel, D. P.; Horvitz, H. R.; Ambros, V. (2005). "The let-7 MicroRNA Family Members mir-48, mir-84, and mir-241 Function Together to Regulate Developmental Timing in Caenorhabditis elegans". Developmental Cell. 9 (3): 403–414. doi:10.1016/j.devcel.2005.07.009. PMC 3969732. PMID 16139228.

v t e miRNA precursor families
1-100	1 2 3 5 6 7 8/141/200 9/79 10 11 14 15 16 17 19 21 22 23 24 25 26 28 29 30 31 32 33 34 42 46/47/281 48 52 58 61 62 67 71 84 92 96
101-200	101 103/107 122 124 126 127 129 130 132 133 134 135 137 138 141 143 144 145 146 148/152 150 153 154 155 156 160 166 172 181 184 185 186 187 188 190 191 192/215 193 194 196 198 199 200
201-300	202 203 203a 205 208 210 212 214 216 218 219 221 223 224 241 275 277 278 279 281 282 296 299
301-400	301 305 322 326 330 331 337 338 339 340 344 345 346 350 351 361 363 365 367 370 374 383 384 390 394 395 396 397 398 399
401-500	403 408 423 425 430 431 432 433 434 444 448 449 451 452 454 455 474 484 488 489 491 492 497 498 500
501-600	503 504 505 506 529 535 541 542 544 548 549 550 552 558 562 569 572 575 580 584 589 590 592 598
601+	601 605 612 615 612 612 624 625 632 633 636 638 650 652 657 661 663 671 672 675 708 711 720 744 764 765 767 786 802 824 828 854 872 873 874 885 938 939 3180
Other	BART1 BART2 BHRF1-1 BHRF1-2 BHRF1-3 Let-7 Lin-4 Lsy-6

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